Technology Process of 2,6-Diethyl-3,4-dihydro-3,5-dimethyl-2H-pyran
There total 10 articles about 2,6-Diethyl-3,4-dihydro-3,5-dimethyl-2H-pyran which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) yeast: Levure Alsacienne/sugar / 2.) Raney-Ni / !.) water/methanol, 3 d, 2.) methanol, reflux
2: imidazole / dimethylformamide / 36 h / 20 °C
3: 92 percent / DIBAH / diethyl ether; hexane / 12 h / -70 - 0 °C
4: N,N'-dicyclohexyl-N-methylcarbodiimidium iodide / tetrahydrofuran / 62 h / 60 °C
5: 1.) diisopropylamine/n-butyl lithium / 1.) THF/hexane, 45 min, -78 deg C, 2.) HMPA, 16 h, from -78 deg C to room temp; 1 d, room temp.
6: 1 M tetra-n-butyl ammonium fluoride / tetrahydrofuran / 16 h / Ambient temperature
7: p-toluenesulfonic acid / 80 - 160 °C / 12 Torr
With
1H-imidazole; n-butyllithium; yeast: Levure Alsacienne; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; N,N'-dicyclohexyl-N-methylcarbodiimidium iodide; toluene-4-sulfonic acid; diisopropylamine; Sucrose;
nickel;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N,N'-dicyclohexyl-N-methylcarbodiimidium iodide / tetrahydrofuran / 62 h / 60 °C
2: 1.) diisopropylamine/n-butyl lithium / 1.) THF/hexane, 45 min, -78 deg C, 2.) HMPA, 16 h, from -78 deg C to room temp; 1 d, room temp.
3: 1 M tetra-n-butyl ammonium fluoride / tetrahydrofuran / 16 h / Ambient temperature
4: p-toluenesulfonic acid / 80 - 160 °C / 12 Torr
With
n-butyllithium; tetrabutyl ammonium fluoride; N,N'-dicyclohexyl-N-methylcarbodiimidium iodide; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: imidazole / dimethylformamide / 36 h / 20 °C
2: 92 percent / DIBAH / diethyl ether; hexane / 12 h / -70 - 0 °C
3: N,N'-dicyclohexyl-N-methylcarbodiimidium iodide / tetrahydrofuran / 62 h / 60 °C
4: 1.) diisopropylamine/n-butyl lithium / 1.) THF/hexane, 45 min, -78 deg C, 2.) HMPA, 16 h, from -78 deg C to room temp; 1 d, room temp.
5: 1 M tetra-n-butyl ammonium fluoride / tetrahydrofuran / 16 h / Ambient temperature
6: p-toluenesulfonic acid / 80 - 160 °C / 12 Torr
With
1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; N,N'-dicyclohexyl-N-methylcarbodiimidium iodide; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
