ETHYL 4-NITRO-L-PHENYLALANINE

Base Information

• Chemical Name: ETHYL 4-NITRO-L-PHENYLALANINE
• CAS No.: 34276-53-4
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.243
• Hs Code.: 2922499990
• Mol file: 34276-53-4.mol

Synonyms:(S)-2-Amino-3-(4-nitro-phenyl)-propionic acid ethyl ester;

Chemical Property of ETHYL 4-NITRO-L-PHENYLALANINE

Chemical Property:

• Boiling Point: 372.1 °C at 760 mmHg
• PKA: 6.62±0.33(Predicted)
• Flash Point: 178.9 °C
• PSA: 98.14000
• Density: 1.246 g/cm³
• LogP: 2.25120
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-nitro-L-phenylalanine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-NITRO-L-PHENYLALANINE

There total 8 articles about ETHYL 4-NITRO-L-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride (58816-66-3) → ethyl (S)-2-amino-3-(4-nitrophenyl)propionate (34276-53-4,780004-06-0)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

Reference yield: 98.7%

ethanol (64-17-5) + L-nitrophenylalanine hydrochloride (147065-06-3) → ethyl (S)-2-amino-3-(4-nitrophenyl)propionate (34276-53-4,780004-06-0)

Guidance literature:

With thionyl chloride; at 10 - 60 ℃; for 0.15h; Temperature;

Reference yield: 80.0%

ethanol (64-17-5) + 4-nitro-3-phenyl-L-alanine (949-99-5) → ethyl (S)-2-amino-3-(4-nitrophenyl)propionate (34276-53-4,780004-06-0)

Guidance literature:

With hydrogenchloride; for 3h; Heating;

upstream raw materials:

ethanol

4-nitro-3-phenyl-L-alanine

L-phenylalanine

(S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride

Downstream raw materials:

(S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol

3-(4-nitrophenyl)-2(S)-(3-oxospiro[3.5]non-1-en-1-ylamino)propionic acid ethyl ester

ethyl (S)-3-(4-aminophenyl)-2-(benzyloxycarbonylamino)propionate

ethyl N-[(4R,7S)-7-(benzyloxy)-3-oxospiro[3.5]non-1-en-1-yl]-4-nitro-L-phenylalaninate

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES". Page 45. . Retrieved 2010/02/06.
• 2、 Cazin, Jacques,Duflos, Jack,Dupas, Georges,Bourguignon, Jean,Queguiner, Guy. "Improvement in the Enantioselectivity of the Hydrogen Transfer with NADH Models Bearing Amino Alcohols as Chiral Auxiliaries". . p. 867 - 872. Retrieved 2007/10/02.