TRANS-2,3-DIFLUOROCINNAMIC ACID

Base Information

• Chemical Name: TRANS-2,3-DIFLUOROCINNAMIC ACID
• CAS No.: 236746-13-7
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.142
• Mol file: 236746-13-7.mol

Synonyms:2,3-Difluorocinnamic acid;

Chemical Property of TRANS-2,3-DIFLUOROCINNAMIC ACID

Chemical Property:

• Boiling Point: 281.3 °C at 760 mmHg
• PKA: 4.16±0.10(Predicted)
• Flash Point: 124 °C
• PSA: 37.30000
• Density: 1.379 g/cm³
• LogP: 2.06260
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(2E)-3-(2,3-Difluorophenyl)-2-propenoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2E)-3-(2,3-Difluorophenyl)-2-propenoic Acid, is an intermediate in the synthesis of various pharmaceutical and biologically active compounds.

Technology Process of TRANS-2,3-DIFLUOROCINNAMIC ACID

There total 1 articles about TRANS-2,3-DIFLUOROCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,3-difluorocinnamic acid (236746-13-7)

Guidance literature:

Reference yield:

2,3-difluorocinnamic acid (207981-48-4,236746-13-7) → C9H5ClF2O

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.2h;

DOI:10.1039/d1cc01437d

Reference yield:

2,3-difluorocinnamic acid (236746-13-7) → 4,5-difluoro-2,3-dihydro-1H-inden-1-one (628732-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

2.2: 16 h / 50 °C

With oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium 10% on activated carbon; In ethanol; dichloromethane;

Downstream raw materials:

2-(4,5-difluoro-indan-1-yl)-ethanol

4,5-difluoro-2,3-dihydro-1H-inden-1-one

Refernces