C₂₁H₁₉FN₄O

Base Information

• Chemical Name: C₂₁H₁₉FN₄O
• CAS No.: 1220121-04-9
• Molecular Formula: C₂₁H₁₉FN₄O
• Molecular Weight: 362.406
• Mol file: 1220121-04-9.mol

Synonyms:C₂₁H₁₉FN₄O

Chemical Property of C₂₁H₁₉FN₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₉FN₄O

There total 5 articles about C₂₁H₁₉FN₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173459-03-5) + (S)-3-fluoro-α-methylbenzylamine (444643-09-8) → C21H19FN4O (1220121-04-9)

Guidance literature:

In butan-1-ol; at 145 ℃; for 24h; Inert atmosphere;

DOI:10.1002/mrc.2560

Reference yield:

(R)-(-)-1-(3-fluorophenyl)ethylamine (761390-58-3,444643-09-8) + 4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (173459-03-5) → C21H19FN4O (1220121-04-9)

Guidance literature:

In butan-1-ol; at 145 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.10.012

Reference yield:

2-amino-3-carboxethyl-5-(4-methoxyphenyl)-pyrrole (173458-92-9) → C21H19FN4O (1220121-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C

2.1: trichlorophosphate / 3 h / 90 °C

2.2: pH 12

3.1: butan-1-ol / 24 h / 145 °C / Inert atmosphere

With formic acid; trichlorophosphate; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1016/j.ejmech.2011.10.012

upstream raw materials:

4-chloro-6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine

(S)-3-fluoro-α-methylbenzylamine

2-amino-3-carboxethyl-5-(4-methoxyphenyl)-pyrrole

(R)-(-)-1-(3-fluorophenyl)ethylamine

Downstream raw materials:

(R)-4-(4-((1-(3-fluorophenyl)ethyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenol hydrobromide

C₂₀H₁₇FN₄O

Refernces

• 1、 Kaspersen, Svein Jacob,Sorum, Christopher,Willassen, Veronica,Fuglseth, Erik,Kjobli, Eli,Bjorkoy, Geir,Sundby, Eirik,Hoff, Brd Helge. "Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines". . p. 6002 - 6014. Retrieved 2012/01/02.