METHYL 5-CYANOVALERATE

Base Information

• Chemical Name: METHYL 5-CYANOVALERATE
• CAS No.: 3009-88-9
• Molecular Formula: C7H11 N O2
• Molecular Weight: 141.17
• Hs Code.: 2926909090
• Mol file: 3009-88-9.mol

Synonyms:Valericacid, 5-cyano-, methyl ester (6CI,7CI,8CI); Methyl 5-cyanopentanoate; Methyl5-cyanovalerate; Methyl d-cyanovalerate

Chemical Property of METHYL 5-CYANOVALERATE

Chemical Property:

• PSA: 50.09000
• LogP: 1.24338

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 5-CYANOVALERATE

There total 22 articles about METHYL 5-CYANOVALERATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sulfolane (126-33-0,208252-54-4) + cis-2-pentenenitrile (25899-50-7) + 2-pentenenitrile (26294-98-4) → 5-cyanopentanoic acid methyl ester (3009-88-9)

Guidance literature:

In methanol;

Reference yield: 78.0%

sulfolane (126-33-0,208252-54-4) + 2-pentenenitrile (26294-98-4) → 5-cyanopentanoic acid methyl ester (3009-88-9)

Guidance literature:

In methanol;

Reference yield: 75.1%

4-Pentenenitrile (592-51-8) → 5-cyanopentanoic acid methyl ester (3009-88-9)

Guidance literature:

With pyridine; In methanol; carbon monoxide; acetone;

upstream raw materials:

methyl 5-chloropentanoate

potassium cyanide

5-Cyano-orthopentansaeure-trimethylester

O-methylcaprolactim

Downstream raw materials:

Adipic acid

3,4-dihydro-1H-isoquinoline-2-carboxylic acid 5-[1-(cyclopropylcarbamoyl-hydroxy-methyl)-butylcarbamoyl]-1-[3-methyl-2-(3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (3R,5S)-5-(1-cyclopropylaminooxalyl-butylcarbamoyl)-1-[(S)-3-methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-pyrrolidin-3-yl ester

(1S,3aR,6aS)-2-[(S)-3-Methyl-2-((S)-3-methyl-2-{5-[1-(1-methyl-1-phenyl-ethyl)-1H-tetrazol-5-yl]-pentanoylamino}-butyrylamino)-butyryl]-octahydro-cyclopenta[c]pyrrole-1-carboxylic acid [1-(cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-amide

Refernces

• 1、 Nobbs, James D.,Low, Choon Heng,Stubbs, Ludger P.,Wang, Cun,Drent, Eite,Van Meurs, Martin. "Isomerizing Methoxycarbonylation of Alkenes to Esters Using a Bis(phosphorinone)xylene Palladium Catalyst". . p. 391 - 398. Retrieved 2017/04/26.
• 2、 Sun, David X.,Liu, Lifei,Heinz, Beverly,Kolykhalov, Alexander,Lamar, Jason,Johnson, Robert B.,Wang, Q. May,Yip, Yvonne,Chen, Shu-Hui. "P4 cap modified tetrapeptidyl α-ketoamides as potent HCV NS3 protease inhibitors". . p. 4333 - 4338. Retrieved 2007/10/03.