5-Fluoroorthanilic acid (SO3H=1)

Base Information

• Chemical Name: 5-Fluoroorthanilic acid (SO3H=1)
• CAS No.: 393-42-0
• Molecular Formula: C6H6 F N O3 S
• Molecular Weight: 191.1801432
• Hs Code.: 2921420090
• Mol file: 393-42-0.mol

Synonyms:2-Amino-5-fluorobenzenesulfonicacid

Chemical Property of 5-Fluoroorthanilic acid (SO3H=1)

Chemical Property:

• PSA: 88.77000
• LogP: 2.31660

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoroorthanilic acid (SO3H=1)

There total 5 articles about 5-Fluoroorthanilic acid (SO3H=1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-fluorobenzothiazole (118220-71-6) → 2-amino-5-fluorobenzenesulfonic acid (393-42-0)

Guidance literature:

With [RuCl(P(C₆H₅)3)2(O(C₆H₄)NCH(C₄H₃N))]; bromamine B; sodium hydroxide; In water; acetonitrile; at 39.84 ℃; for 5.58333h;

DOI:10.1016/j.molcata.2010.06.006

Reference yield:

4'-fluoroacetanilide (351-83-7) → 2-amino-5-fluorobenzenesulfonic acid (393-42-0)

Guidance literature:

With sulfuric acid; at 180 ℃;

DOI:10.1021/ja01860a050

Reference yield:

4-fluoroaniline (371-40-4) → 2-amino-5-fluorobenzenesulfonic acid (393-42-0)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sulfuric acid; Yield given. Multistep reaction; 1.) H₂O, 40 deg C, 30 min; 2.) the dried product at 235 deg C heating, 5 h, then H₂O, 90 deg C 15 min; 3.) H₂₀ pH 1.6;

DOI:10.1002/hlca.19820650212

upstream raw materials:

4'-fluoroacetanilide

4-fluoroaniline

sulfuric acid

6-fluorobenzothiazole

Downstream raw materials:

2,6-dibromo-4-fluoroaniline

N-nitro-N-(2,6-dibromo-4-fluorophenyl)-N'-(4-methoxyphenyl)urea

N-nitro-N-(2,6-dibromo-4-fluorophenyl)-N'-(4-chlorophenyl)urea

N-nitro-N-(2,6-dibromo-4-fluorophenyl)-N'-(2,3-dimethylphenyl)urea

Refernces

• 1、 Jagadeesh,Karthikeyan,Nithya,Sandhya, Y. Sree,Reddy, S. Sudhaker,Reddy, P. Pradeep Kumar,Kumar, M. Vinod,Charan, K.T. Prabhu,Narender,Bhagat. "Development of an efficient ruthenium catalyzed synthetic process and mechanism for the facile conversion of benzothiazoles to orthanilic acids". experimental part. p. 99 - 107. Retrieved 2010/12/18.