Bis-(4-fluoro-phenyl)-aceticacidethylester

Base Information

• Chemical Name: Bis-(4-fluoro-phenyl)-aceticacidethylester
• CAS No.: 386-99-2
• Molecular Formula: C16H14 F2 O2
• Molecular Weight: 276.283
• Hs Code.: 2916399090
• Mol file: 386-99-2.mol

Synonyms:Aceticacid, bis(p-fluorophenyl)-, ethyl ester (6CI,8CI)

Chemical Property of Bis-(4-fluoro-phenyl)-aceticacidethylester

Chemical Property:

• PSA: 26.30000
• LogP: 3.65980

Purity/Quality:

BIS-(4-FLUORO-PHENYL)-ACETIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bis-(4-fluoro-phenyl)-aceticacidethylester

There total 8 articles about Bis-(4-fluoro-phenyl)-aceticacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl acetate (141-78-6) + 1-Bromo-4-fluorobenzene (460-00-4) → ethyl 2,2-bis(4-fluorophenyl)acetate (386-99-2)

Guidance literature:

With potassium phosphate; (1,10-phenanthroline)(triphenylphosphine)CuBr; tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201100172

Reference yield: 90.0%

1,2-bis(4-fluorophenyl)-2-hydroxyethan-1-one (53458-16-5) + orthoformic acid triethyl ester (122-51-0) → ethyl 2,2-bis(4-fluorophenyl)acetate (386-99-2)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; stereospecific reaction;

DOI:10.1021/ol500292c

Reference yield: 70.0%

ethanol (64-17-5) + 1,2-bis(4-fluorophenyl)ethane-1,2-dione (579-39-5) → ethyl 2,2-bis(4-fluorophenyl)acetate (386-99-2)

Guidance literature:

With 5,6-bis(5-methoxythiophen-2-yl)pyrazine-2,3-dicarbonitrile; triethyl phosphite; In 1,2-dichloro-ethane; at 20 ℃; for 48h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1002/anie.202107080

upstream raw materials:

ethanol

2,2-bis(4-fluorophenyl)acetic acid

1,1,1-trifluoro-2,2-bis(p-fluorophenyl)ethane

2,2,2-trifluoro-1,1-bis(4-fluorophenyl)ethanol

Downstream raw materials:

ethyl 4-cyano-2,2-bis(4-fluorophenyl)butanoate

ethyl 3-cyano-2,2-bis(4-fluorophenyl)propanoate

3,3-bis(4-fluorophenyl)pyrrolidin-2-one

ethyl 2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)acetate

Refernces

• 1、 -. "Diaryl acetate compound and preparation method thereof". Paragraph 0028-0030. . Retrieved 2020/04/29.
• 2、 Song, Bingrui,Himmler, Thomas,Goossen, Lukas J.. "Palladium/copper-catalyzed Di-α-arylation of acetic acid esters". supporting information; experimental part. p. 1688 - 1694. Retrieved 2011/09/14.