2-BROMO-3-CHLOROBENZOTRIFLUORIDE

Base Information

• Chemical Name: 2-BROMO-3-CHLOROBENZOTRIFLUORIDE
• CAS No.: 384-16-7
• Molecular Formula: C7H3 Br Cl F3
• Molecular Weight: 259.453
• Hs Code.: 2903999090
• Mol file: 384-16-7.mol

Synonyms:Toluene,2-bromo-3-chloro-a,a,a-trifluoro- (8CI)

Chemical Property of 2-BROMO-3-CHLOROBENZOTRIFLUORIDE

Chemical Property:

• Vapor Pressure: 0.507mmHg at 25°C
• Refractive Index: 1.491
• Boiling Point: 198.4°Cat760mmHg
• Flash Point: 73.8°C
• PSA: 0.00000
• Density: 1.717g/cm³
• LogP: 4.12130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

2-Bromo-1-chloro-3-(trifluoromethyl)benzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-3-CHLOROBENZOTRIFLUORIDE

There total 3 articles about 2-BROMO-3-CHLOROBENZOTRIFLUORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-bromo-3-chloro-5-(trifluoromethyl)aniline (914225-58-4) → 2-bromo-1-chloro-3-(trifluoromethyl)benzene (384-16-7)

Guidance literature:

4-bromo-3-chloro-5-(trifluoromethyl)aniline; With sulfuric acid; sodium nitrite; In tetrahydrofuran; water; at -5 ℃; for 1h;

With phosphinic acid; In tetrahydrofuran; water; for 8h;

Reference yield:

2-bromo-5-nitro-benzotrifluoride (367-67-9) → 2-bromo-1-chloro-3-(trifluoromethyl)benzene (384-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chlorine; sulfuric acid / 60 °C

2.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux

3.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C

3.2: 8 h

With sulfuric acid; chlorine; ammonium chloride; zinc; sodium nitrite; In tetrahydrofuran; ethanol; water;

Reference yield:

2-bromo-3-trifluoromethyl-5-nitro-chlorobenzene (914225-53-9) → 2-bromo-1-chloro-3-(trifluoromethyl)benzene (384-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux

2.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C

2.2: 8 h

With sulfuric acid; ammonium chloride; zinc; sodium nitrite; In tetrahydrofuran; ethanol; water;

upstream raw materials:

2-bromo-5-nitro-benzotrifluoride

2-bromo-3-trifluoromethyl-5-nitro-chlorobenzene

4-bromo-3-chloro-5-(trifluoromethyl)aniline

Downstream raw materials:

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

2-deutero-1-chloro-3-(trifluoromethyl)benzene

Refernces