METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE

Base Information

• Chemical Name: METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE
• CAS No.: 378-67-6
• Molecular Formula: C4H3 Br F4 O2
• Molecular Weight: 238.964
• Hs Code.: 2915907098
• Mol file: 378-67-6.mol

Synonyms:Propionicacid, 2-bromo-2,3,3,3-tetrafluoro-, methyl ester (6CI,8CI); Methyl2-bromo-2,3,3,3-tetrafluoropropanoate

Chemical Property of METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE

Chemical Property:

• Refractive Index: 1.3617
• Boiling Point: 106.0-106.5
• PSA: 26.30000
• Density: 1.656
• LogP: 1.78240

Purity/Quality:

97.00% ^*data from raw suppliers

METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE

There total 5 articles about METHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methanol (67-56-1) + 2-bromohexafluoropropyl fluorosulfate (41255-95-2) → 2-bromo-2,3,3,3-tetrafluoro-propionic acid methyl ester (378-67-6)

Guidance literature:

With potassium fluoride;

Reference yield:

Hexafluoropropene oxide (428-59-1,25038-02-2) + diethylene glycol dimethyl ether (111-96-6) → 2-bromo-2,3,3,3-tetrafluoro-propionic acid methyl ester (378-67-6) + 2,3,3,3-tetrafluoro-2-bromopropanoyl fluoride (6129-62-0)

Guidance literature:

With sodium bromide; at -30 ℃;

DOI:10.1007/s11167-005-0577-4

Reference yield:

(1,2-dibromo-1,2,3,3,3-pentafluoro-propyl)-methyl ether (374-94-7) → 2-bromo-2,3,3,3-tetrafluoro-propionic acid methyl ester (378-67-6)

Guidance literature:

With sulfuric acid; water;

upstream raw materials:

(1,2-dibromo-1,2,3,3,3-pentafluoro-propyl)-methyl ether

methanol

2-bromohexafluoropropyl fluorosulfate

2,3,3,3-tetrafluoro-2-bromopropanoyl fluoride

Downstream raw materials:

2-bromo-2,3,3,3-tetrafluoropropionamide

2-(1-benzyl-2-methyl-1H-indol-4-yloxy)-2-bromo-3,3,3-trifluoro-propionic acid methyl ester

C₂₀H₁₇F₄NO₃

Methyl 2-(1-benzyl-2-methyl-1H-indol-4-yloxy)-3-bromo-2,3,3-trifluoropropanoate

Refernces

• 1、 Coe, Paul L.,Loehr, Marianne,Rochin, Christophe. "Reactions involving hexafluoropropylene oxide: Novel ring opening reactions and resolution of a racemic mixture of a bromofluoro ester, ultrasound mediated Reformatsky reactions and stereoselectivity". . p. 2803 - 2811. Retrieved 2007/10/03.