Technology Process of N-methyl-2-[2-oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazol-3(2H)-yl]-N-phenylacetamide
There total 7 articles about N-methyl-2-[2-oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzoxazol-3(2H)-yl]-N-phenylacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; tricyclohexylphosphine;
In
1,4-dioxane;
at 20 ℃;
for 15h;
Inert atmosphere;
Reflux;
DOI:10.1055/s-0033-1339799
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice; Inert atmosphere
3: hydrogenchloride; acetic acid / 1,4-dioxane / 6.5 h / 50 °C / Inert atmosphere
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere
5: tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; potassium acetate / 1,4-dioxane / 15 h / 20 °C / Inert atmosphere; Reflux
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339799
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 5% rhodium-on-charcoal; hydrogen / tetrahydrofuran / 11 h / 20 °C / Inert atmosphere
2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice; Inert atmosphere
4: hydrogenchloride; acetic acid / 1,4-dioxane / 6.5 h / 50 °C / Inert atmosphere
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 6 h / 20 °C / Inert atmosphere
6: tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine; potassium acetate / 1,4-dioxane / 15 h / 20 °C / Inert atmosphere; Reflux
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); 5% rhodium-on-charcoal; hydrogen; potassium acetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339799