2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

Base Information

• Chemical Name: 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt
• CAS No.: 126962-22-9
• Molecular Formula: C₁₅H₂₁O₅S*Na
• Molecular Weight: 336.385
• Mol file: 126962-22-9.mol

Synonyms:2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

Chemical Property of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt

There total 2 articles about 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.7%

sodium 2-hydroxyethanesulfonate (1562-00-1) + (+/-)-2-(4-isobutylphenyl)propanoyl chloride (71381-91-4,114978-05-1,115588-20-0,34715-60-1) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt (126962-22-9)

Guidance literature:

With pyridine; at 130 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm101403g

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt (126962-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 25 °C

2: pyridine / 4 h / 130 °C / Inert atmosphere

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm101403g

Reference yield: 51.7%

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonic acid sodium salt (126962-22-9) → 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride (1268343-96-9)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

DOI:10.1021/jm101403g

upstream raw materials:

ibuprofen

sodium 2-hydroxyethanesulfonate

(+/-)-2-(4-isobutylphenyl)propanoyl chloride

Downstream raw materials:

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonyl chloride

2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylhydroxamic acid

N-methoxyl 2-[2-(4-isobutylphenyl)propionoyloxy]ethanesulfonylamide

Refernces