2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide

Base Information

• Chemical Name: 2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide
• CAS No.: 351-33-7
• Molecular Formula: C9H6 Cl2 F3 N O
• Molecular Weight: 272.054
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID10367999
• Wikidata: Q82154262
• Mol file: 351-33-7.mol

Synonyms:2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide;351-33-7;2-Chloro-N-(4-chloro-3-trifluoromethyl-phenyl)-acetamide;2-CHLORO-N-(4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE;SCHEMBL4443052;DTXSID10367999;MFCD00467443;STK983702;AKOS000369997;BS-10027;CS-0116899;EN300-01525;SR-01000036856;SR-01000036856-1;Z56862377;2-chloro-N-(4-chloro-3-trifluoromethylphenyl)-acetamide;2-Chloro-N-(4-chloro-3-trifluoro methyl phenyl)-acetamide

Chemical Property of 2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide

Chemical Property:

• PSA: 29.10000
• LogP: 3.60910
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 270.9778537
• Heavy Atom Count: 16
• Complexity: 260

Purity/Quality:

99%min ^*data from raw suppliers

2-Chloro-N-(4-chloro-3-trifluoromethyl-phenyl)-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1NC(=O)CCl)C(F)(F)F)Cl

Technology Process of 2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide

There total 2 articles about 2-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

chloroacetyl chloride (79-04-9) + 4-chloro-3-trifluoromethyl-aniline (320-51-4) → [(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride (351-33-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1002/anie.201405035

Reference yield:

→ [(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride (351-33-7)

Guidance literature:

4-Chlor-3-trifluormethyl-anilin, Chloracetylchlorid;

Reference yield: 48.0%

3-(pyridin-4-yloxy)aniline (102877-77-0) + [(4-chloro-3-trifluoromethylphenyl)aminocarbonylmethyl]chloride (351-33-7) → N-(4-chloro-3-trifluoromethylphenyl)-2-[3-(4-pyridinyloxy)phenylamino]acetamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 6h;

upstream raw materials:

chloroacetyl chloride

4-chloro-3-trifluoromethyl-aniline

Downstream raw materials:

N-(4-chloro-3-trifluoromethylphenyl)-2-[(R)-1-(3,4-dimethoxyphenyl)-ethylamino]-acetamide

2-(4-bromo-phenoxy)-N-(4-chloro-3-trifluoromethyl-phenyl)acetamide

N-[4-chloro-3-(trifluoromethyl)phenyl]-2-{[4-(5-hydroxy-1H-tetrazol-1-yl)phenyl]oxy}acetamide

N'-[4-chloro-3-(trifluoromethyl)phenyl]-N-[3-(1H-tetrazol-1-yl)phenyl]glycinamide

Refernces

• 1、 Hovey, M. Todd,Check, Christopher T.,Sipher, Alexandra F.,Scheidt, Karl A.. "N-heterocyclic-carbene-catalyzed synthesis of 2-aryl indoles". supporting information. p. 9603 - 9607. Retrieved 2014/10/15.
• 2、 -. "HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS". Page/Page column 43. . Retrieved 2008/06/13.