2-Fluoro-4-nitro-benzamide

Base Information

• Chemical Name: 2-Fluoro-4-nitro-benzamide
• CAS No.: 350-32-3
• Molecular Formula: C7H5 F N2 O3
• Molecular Weight: 184.127
• Hs Code.: 2924299090
• Mol file: 350-32-3.mol

Synonyms:2-Fluoro-4-nitrobenzamide

Chemical Property of 2-Fluoro-4-nitro-benzamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 317.61°C at 760 mmHg
• Flash Point: 145.885°C
• PSA: 88.91000
• Density: 1.483g/cm³
• LogP: 2.05630
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-4-nitrobenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-4-nitrobenzamide

Technology Process of 2-Fluoro-4-nitro-benzamide

There total 4 articles about 2-Fluoro-4-nitro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-fluoro-4-nitrobenzoic acid (403-24-7) → 2-fluoro-4-nitrobenzamide (350-32-3)

Guidance literature:

2-fluoro-4-nitrobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 25 ℃; for 4h;

With ammonia; In water; for 0.166667h;

Reference yield:

2-fluoro-4-nitrobenzoyl chloride (403-23-6) → 2-fluoro-4-nitrobenzamide (350-32-3)

Guidance literature:

With diethyl ether; ammonia;

DOI:10.1002/hlca.19510340515

Reference yield:

2-fluoro-4-nitrotoluene (1427-07-2) → 2-fluoro-4-nitrobenzamide (350-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / aq. CrO₃; H₂SO₄; AcOH / 20 - 100 °C

2: (COCl)2; DMF / tetrahydrofuran / 3 h / 0 - 20 °C

3: 15.5 g / NH₃ gas / tetrahydrofuran / 2.5 h / 0 °C

With chromium(VI) oxide; oxalyl dichloride; sulfuric acid; ammonia; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1021/jm010244+

upstream raw materials:

2-fluoro-4-nitrobenzoyl chloride

2-fluoro-4-nitrobenzoic acid

2-fluoro-4-nitrotoluene

Refernces

• 1、 Xu, Xi,Ge, Raoling,Li, Lei,Wang, Jubo,Lu, Xiaoyu,Xue, Siqi,Chen, Xijing,Li, Zhiyu,Bian, Jinlei. "Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti-prostate cancer agents". . p. 1325 - 1344. Retrieved 2017/11/13.
• 2、 -. "SUBSTITUTED OXOPYRIDINE DERIVATIVES". Paragraph 0475-0476; 0491-0494. . Retrieved 2017/11/07.