(4-FLUORO-PHENYL)-PHOSPHONIC ACID

Base Information

• Chemical Name: (4-FLUORO-PHENYL)-PHOSPHONIC ACID
• CAS No.: 349-87-1
• Molecular Formula: C6H6 F O3 P
• Molecular Weight: 176.084
• Hs Code.: 2931900090
• Mol file: 349-87-1.mol

Synonyms:Phosphonicacid, (4-fluorophenyl)- (9CI); Phosphonic acid, (p-fluorophenyl)-(6CI,7CI,8CI); (p-Fluorophenyl)phosphonic acid

Chemical Property of (4-FLUORO-PHENYL)-PHOSPHONIC ACID

Chemical Property:

• PSA: 67.34000
• LogP: 0.62870

Purity/Quality:

98%min ^*data from raw suppliers

(4-FLUORO-PHENYL)-PHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-FLUORO-PHENYL)-PHOSPHONIC ACID

There total 7 articles about (4-FLUORO-PHENYL)-PHOSPHONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

diethyl (4-fluorophenyl)phosphonate (310-40-7) → (4-fluorophenyl)phosphonic acid (349-87-1)

Guidance literature:

With trimethylsilyl bromide; at 20 ℃;

DOI:10.1016/j.poly.2018.02.030

Reference yield: 88.0%

4-fluorophenylphosphonic dichloride (657-81-8) → (4-fluorophenyl)phosphonic acid (349-87-1)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

Reference yield:

fluorobenzene (462-06-6) → (4-fluorophenyl)phosphonic acid (349-87-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / PCl₃ / Lewis acid

2: 84 percent / DMSO / CH₂Cl₂ / 0.5 h / -76 °C

3: 88 percent / conc. HCl / 8 h / Heating

With hydrogenchloride; dimethyl sulfoxide; phosphorus trichloride; Lewis acid; In dichloromethane;

upstream raw materials:

4-fluorophenylphosphonic dichloride

para-fluorophenylphosphonous dichloride

fluorobenzene

diethyl (4-fluorophenyl)phosphonate

Downstream raw materials:

(4-fluoro-3-nitro-phenyl)-phosphonic acid

Refernces

• 1、 -. "For organic electronic device, modified stable electrode having a work function and method". Paragraph 0040. . Retrieved 2017/01/05.
• 2、 -. "Stable electrodes with modified work functions and methods for organic electronic devices". . . Retrieved 2011/06/10.