1,2-Bis(4-fluorophenyl)hydrazine

Base Information

• Chemical Name: 1,2-Bis(4-fluorophenyl)hydrazine
• CAS No.: 332-06-9
• Molecular Formula: C12H10 F2 N2
• Molecular Weight: 220.222
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID401302657
• Nikkaji Number: J3.350.008D
• Mol file: 332-06-9.mol

Synonyms:1,2-bis(4-fluorophenyl)hydrazine;332-06-9;Hydrazine, 1,2-bis(4-fluorophenyl)-;DTXSID401302657;CS-0166338;1,2-bis(4-fluorophenyl)hydrazine? (Cabozantinib Impurity

Chemical Property of 1,2-Bis(4-fluorophenyl)hydrazine

Chemical Property:

• PSA: 23.79000
• LogP: 1.68508
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 220.08120465
• Heavy Atom Count: 16
• Complexity: 175

Purity/Quality:

98%min ^*data from raw suppliers

N,N’-Bis-(4-fluoro-phenyl)-hydrazine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NNC2=CC=C(C=C2)F)F

Technology Process of 1,2-Bis(4-fluorophenyl)hydrazine

There total 8 articles about 1,2-Bis(4-fluorophenyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

bis-(4-fluorophenyl)diazene (332-07-0,51788-93-3,51789-00-5) + bis(pinacol)diborane (73183-34-3) → (4,4'-difluoro)-1,2-diphenylhydrazine (332-06-9)

Guidance literature:

bis-(4-fluorophenyl)diazene; bis(pinacol)diborane; With pyridine-4-carbonitrile; In pentane; at 70 ℃; for 24h; Inert atmosphere;

With water; In pentane; at 20 ℃; for 0.25h;

Reference yield: 95.0%

bis-(4-fluorophenyl)diazene (332-07-0,51788-93-3,51789-00-5) → (4,4'-difluoro)-1,2-diphenylhydrazine (332-06-9)

Guidance literature:

With borane-ammonia complex; [C₆H₃-2,6-(CHN(t-Bu))₂]Bi; water; In tetrahydrofuran; at 35 ℃; for 10h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.9b00594

Reference yield: 95.0%

(E)-bis(4-fluorophenyl)diazene (332-07-0) → (4,4'-difluoro)-1,2-diphenylhydrazine (332-06-9)

Guidance literature:

With methanol; cesium fluoride; bis(pinacol)diborane; at 20 ℃; for 4h; Irradiation;

DOI:10.1021/acs.joc.1c00394

upstream raw materials:

bis-(4-fluorophenyl)diazene

N,N'-Bis-(4-fluoro-phenyl)-diazene N-oxide

(E)-bis(4-fluorophenyl)diazene

4-fluoroaniline

Downstream raw materials:

(E)-bis(4-fluorophenyl)diazene

1,2-bis(4-fluorophenyl)diazene oxide

1,2-bis-(4-fluoro-phenyl)-pyrazolidine-3,5-dione

bis-(4-fluorophenyl)diazene

Refernces

• 1、 Song, Menghui,Zhou, Hongyan,Wang, Ganggang,Ma, Ben,Jiang, Yajing,Yang, Jingya,Huo, Congde,Wang, Xi-Cun. "Visible-Light-Promoted Diboron-Mediated Transfer Hydrogenation of Azobenzenes to Hydrazobenzenes". . p. 4804 - 4811. Retrieved 2021/04/06.
• 2、 Chang, Liu,Li, Jin,Wu, Na,Cheng, Xu. "Chemoselective electrochemical reduction of nitroarenes with gaseous ammonia". supporting information. p. 2468 - 2472. Retrieved 2021/04/02.