6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC)

Base Information

• Chemical Name: 6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC)
• CAS No.: 325-13-3
• Molecular Formula: C10H6F3N
• Molecular Weight: 197.15700
• Hs Code.: 2933499090
• Mol file: 325-13-3.mol

Synonyms:6-Trifluoromethylquinoline;

Chemical Property of 6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC)

Chemical Property:

• Vapor Pressure: 0.049mmHg at 25°C
• Melting Point: 39 °C
• Refractive Index: 1.54
• Boiling Point: 243.70 °C at 760 mmHg
• PKA: 3.87±0.10(Predicted)
• Flash Point: 101.19 °C
• PSA: 12.89000
• Density: 1.31 g/cm³
• LogP: 3.25360

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Trifluoromethylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC)

There total 18 articles about 6-(TRIFLUOROMETHYL)QUINOLINE,95% MIN(HPLC) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-iodoquinoline (13327-31-6) + Chlorodifluoromethane (75-45-6) → 6-(trifluoromethyl) quinolone (325-13-3)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 120 ℃; for 5h; Mechanism; Sealed tube; Inert atmosphere;

DOI:10.1021/ol503548s

Reference yield: 86.0%

Quinoline-6-carboxylic acid (10349-57-2) → 6-(trifluoromethyl) quinolone (325-13-3)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride; at 85 ℃; for 24h; Autoclave; Inert atmosphere;

DOI:10.1021/acs.joc.9b03011

Reference yield: 84.0%

6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline (75414-00-5) → 6-(trifluoromethyl) quinolone (325-13-3)

Guidance literature:

With iron oxide surrounded by nitrogen doped graphene shell immobilized on carbon support; In n-heptane; at 100 ℃; for 12h; under 11251.1 Torr; Autoclave;

DOI:10.1021/jacs.5b05674

upstream raw materials:

4-trifluoromethylphenylamine

glycerol

p-nitrobenzotrifluoride

(trifluoromethyl)trimethylsilane

Downstream raw materials:

C₂₀H₁₈F₃NO₂

6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline

6-trifluoromethyl-5,6,7,8-tetrahydroquinoline

ethyl 2-phenyl-6-(trifluoromethyl)quinoline-1(2H)-carboxylate

Refernces

• 1、 -. "TEAD INHIBITORS AND USES THEREOF". Paragraph 00465; 00674. . Retrieved 2020/12/11.
• 2、 Hu, Wei-Qiang,Pan, Shen,Qing, Feng-Ling,Vicic, David A.,Xu, Xiu-Hua. "Nickel-Mediated Trifluoromethylation of Phenol Derivatives by Aryl C?O Bond Activation". . p. 16076 - 16082. Retrieved 2020/07/04.