ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate

Base Information

• Chemical Name: ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate
• CAS No.: 929693-73-2
• Molecular Formula: C₂₅H₂₅F₃N₂O₄S
• Molecular Weight: 506.546
• Mol file: 929693-73-2.mol

Synonyms:ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate

Chemical Property of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate

There total 8 articles about ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromoisobutyrate (600-00-0) → ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate (929693-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 20 - 80 °C

2.1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

3.1: Et₃N / CH₂Cl₂ / 20 °C

With hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm058056x

Reference yield:

2-(4-cyanophenoxy)-2-methylpropionic acid ethyl ester (18672-07-6) → ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate (929693-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

2: Et₃N / CH₂Cl₂ / 20 °C

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm058056x

Reference yield:

4-cyanophenol (767-00-0) → ethyl 2-methyl-2-[(4-{[({4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenyl)oxy]propanoate (929693-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: dimethylformamide / 20 - 80 °C

2.1: H₂; AcOH / Pd/C / ethanol / 8 h / 20 °C / 1500.12 Torr

3.1: Et₃N / CH₂Cl₂ / 20 °C

With hydrogen; sodium hydride; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm058056x

upstream raw materials:

ethyl 2-{[4-(aminomethyl)phenyl]oxy}-2-methylpropanoate

4-methyl-2-[3-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

ethyl 2-bromoisobutyrate

3-trifluoromethylbenzonitrile

Refernces