KYNURAMINE DIHYDROBROMIDE

Base Information

• Chemical Name: KYNURAMINE DIHYDROBROMIDE
• CAS No.: 304-47-2
• Molecular Formula: 2BrH*C₉H₁₂N₂O
• Molecular Weight: 326.031
• Mol file: 304-47-2.mol

Synonyms:1-Propanone,3-amino-1-(2-aminophenyl)-, dihydrobromide (9CI); Propiophenone, 2',3-diamino-,dihydrobromide (7CI,8CI); Kynuramine dihydrobromide

Chemical Property of KYNURAMINE DIHYDROBROMIDE

Chemical Property:

• Vapor Pressure: 7.57E-06mmHg at 25°C
• Boiling Point: 367.3°Cat760mmHg
• Flash Point: 175.9°C
• PSA: 69.11000
• Density: g/cm³
• LogP: 3.99800
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Kynuramine dihydrobromide crystalline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Kynuramine dihydrobromide has been used as a substrate for monoamine oxidase.

Technology Process of KYNURAMINE DIHYDROBROMIDE

There total 5 articles about KYNURAMINE DIHYDROBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

kynuramine methyl carbamate (63637-61-6) → Kynuramine dihydrobromide (304-47-2)

Guidance literature:

With hydrogen bromide; In acetic acid; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.3390/md11020274

Reference yield:

methyl 2-(1-H-indol-3-yl)ethylcarbamate (58635-45-3) → Kynuramine dihydrobromide (304-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / O₃ / acetic acid / 0.5 h / cooling

2: 85 percent / HBr / acetic acid / 12 h / 80 °C

With hydrogen bromide; ozone; In acetic acid;

DOI:10.1021/ol010262l

Reference yield:

tryptamine (61-54-1) → Kynuramine dihydrobromide (304-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / aq. NaOH / ethyl acetate / 0.5 h / 25 °C

2: 70 percent / O₃ / acetic acid / 0.5 h / cooling

3: 85 percent / HBr / acetic acid / 12 h / 80 °C

With sodium hydroxide; hydrogen bromide; ozone; In acetic acid; ethyl acetate;

DOI:10.1021/ol010262l

upstream raw materials:

kynuramine methyl carbamate

tryptamine

methyl 2-(1-H-indol-3-yl)ethylcarbamate

2,3-dihydro-Nb-methoxycarbonyl-2-oxotriptamine

Downstream raw materials:

amphimedine

O-methyl styelsamine-N¹⁴-3-phenylpropanamide

O-methyl styelsamine-N¹⁴-2-phenylacetamide

cystodytin-N¹⁴-3-phenylpropanamide

Refernces

• 1、 Fong, Hugo K.H.,Copp, Brent R.. "Synthesis, DNA binding and antitumor evaluation of styelsamine and cystodytin analogues". . p. 274 - 299. Retrieved 2013/05/21.