BOC-D-MET-OSU

Base Information

• Chemical Name: BOC-D-MET-OSU
• CAS No.: 26060-98-0
• Molecular Formula: C14H22 N2 O6 S
• Molecular Weight: 346.4
• Mol file: 26060-98-0.mol

Synonyms:Carbamicacid, [(1R)-1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-3-(methylthio)propyl]-,1,1-dimethylethyl ester (9CI); Carbamic acid,[1-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-3-(methylthio)propyl]-,1,1-dimethylethyl ester, (R)-; Succinimide, N-[(N-carboxy-D-methionyl)oxy]-,tert-butyl ester (8CI); Methionine, N-carboxy-, N-tert-butyl ester, succinimidoderiv., D- (8CI)

Chemical Property of BOC-D-MET-OSU

Chemical Property:

• PKA: 10.57±0.46(Predicted)
• PSA: 127.31000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 1.56880
• Storage Temp.: -15°C

Purity/Quality:

≥98%, ^*data from raw suppliers

BOC-D-MET-OSU ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-MET-OSU

There total 2 articles about BOC-D-MET-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-methionine (348-67-4,26062-47-5,58576-49-1) → Boc-D-Met-OSu (26060-98-0)

Guidance literature:

Multi-step reaction with 2 steps

2: dicyclohexylcarbodiimide

With dicyclohexyl-carbodiimide;

DOI:10.1039/DT9840002305

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + (R)-N-(tert-butoxycarbonyl)methionine (5241-66-7) → Boc-D-Met-OSu (26060-98-0)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1039/DT9840002305

Reference yield: 83.0%

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) + Boc-D-Met-OSu (26060-98-0) → Boc-D-Met-Phe-OMe (99909-57-6)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1021/jm00109a019

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

(R)-N-(tert-butoxycarbonyl)methionine

D-methionine

Downstream raw materials:

Boc-D-Met-Phe-OMe

H-D-Met-Phe-OMe trifluoroacetate

Refernces