N,N-diethyl-2-(4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N,N-diethyl-2-(4-methoxyphenyl)acetamide
• CAS No.: 115348-15-7
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 115348-15-7.mol

Synonyms:N,N-diethyl-2-(4-methoxyphenyl)acetamide

Chemical Property of N,N-diethyl-2-(4-methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 4.6E-05mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

N,N-DIETHYL-2-(4-METHOXYPHENYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diethyl-2-(4-methoxyphenyl)acetamide

There total 17 articles about N,N-diethyl-2-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethylacetamide (685-91-6) + 1-bromo-4-methoxy-benzene (104-92-7) → N,N-diethyl-2-(4-methoxyphenyl)acetamide (115348-15-7)

Guidance literature:

With N-(dicyclohexylphosphino)-2-(2'-methylphenyl)-1H-indole; palladium diacetate; lithium tert-butoxide; In toluene; at 110 ℃; chemoselective reaction; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1002/adsc.201300851

Reference yield: 94.0%

4-Methoxyphenylacetic acid (104-01-8) + triethylamine (121-44-8) → N,N-diethyl-2-(4-methoxyphenyl)acetamide (115348-15-7)

Guidance literature:

With tetrachloromethane; copper(l) iodide; sodium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1002/ejoc.201402332

Reference yield: 91.0%

1-bromo-4-methoxy-benzene (104-92-7) + N,N-Diaethylamino-carbonylmethyl-zinkbromid (50653-15-1) → N,N-diethyl-2-(4-methoxyphenyl)acetamide (115348-15-7)

Guidance literature:

With pentaphenylferrocenyl di-tert-butylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 20 ℃; for 6h;

DOI:10.1021/ja036792p

upstream raw materials:

diethylamine

4-methoxyphenyl-acetic chloride

diethyl amine hydrochloride

2-chloro-1-(4-methoxyphenyl)-2-(phenylsulfinyl)-1-ethanone

Downstream raw materials:

2-(4-(tert-butyl)phenyl)-N,N-diethyl-2-(4-methoxyphenyl)acetamide

N,N-diethyl-2,2-bis(4-methoxyphenyl)acetamide

N,N-diethyl-2-(4-methoxyphenyl)acrylamide

2-(4-Methoxyphenyl)ethanol

Refernces

• 1、 Wang, Biyun,Zhao, Xianghu,Liu, Qingyun,Cao, Song. "Direct defluorinative amidation-hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines". . p. 8546 - 8552. Retrieved 2018/12/01.
• 2、 Allen, Annette D.,Andraos, John,Tidwell, Thomas T.,Vukovic, Sinisa. "Ketene reactions with tertiary amines". supporting information. p. 679 - 685. Retrieved 2014/04/03.