1-(4-CHLOROPHENOXY)-2-PROPANONE

Base Information

• Chemical Name: 1-(4-CHLOROPHENOXY)-2-PROPANONE
• CAS No.: 18859-35-3
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Hs Code.: 2914700090
• Mol file: 18859-35-3.mol

Synonyms:2-Propanone,(p-chlorophenoxy)- (7CI);2-Propanone, 1-(p-chlorophenoxy)- (8CI);(4-Chlorophenoxy)acetone;1-(4-Chlorophenoxy)-2-propanone;NSC 45653;

Chemical Property of 1-(4-CHLOROPHENOXY)-2-PROPANONE

Chemical Property:

• Vapor Pressure: 0.00782mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 268.1 °C at 760 mmHg
• Flash Point: 114.2 °C
• PSA: 26.30000
• Density: 1.187 g/cm³
• LogP: 2.30780

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-chlorophenoxy)acetone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-CHLOROPHENOXY)-2-PROPANONE

There total 9 articles about 1-(4-CHLOROPHENOXY)-2-PROPANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

→ 4-chlorophenoxyacetone (18859-35-3)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

With potassium iodide; In acetone; for 3h; Reflux;

Reference yield: 82.0%

4-chloro-phenol (106-48-9,82344-39-6) + chloroacetone (78-95-5) → 4-chlorophenoxyacetone (18859-35-3)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1039/d1cc05684k

Reference yield: 67.0%

diazoacetone (2684-62-0) + 4-chloro-phenol (106-48-9,82344-39-6) → 4-chlorophenoxyacetone (18859-35-3)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; at 20 ℃; for 12h; Further Variations:; Reagents; Kinetics;

DOI:10.1021/jo0350312

upstream raw materials:

4-chloro-phenol

chloroacetone

1-bromoacetone

1-allyloxy-4-chlorobenzene

Downstream raw materials:

[β-(4-chloro-phenoxy)-isopropyl]-methyl-amine

sulfate de la N-<(1-<4'-chlorophenoxymethyl>ethylidene)amino>-N'-hydroxyguanidine

4-chlorophenoxyacetone oxime

1-Chloro-4-(2-cyclopropylidene-propoxy)-benzene

Refernces

• 1、 Kusaka, Satoshi,Ohmura, Toshimichi,Suginome, Michinori. "Iridium-catalyzed enantioselective intramolecular hydroarylation of allylic aryl ethers devoid of a directing group on the aryl group". supporting information. p. 13542 - 13545. Retrieved 2021/12/23.
• 2、 Hong, Dachao,Kon, Yoshihiro,Shimoyama, Yoshihiro,Tamura, Satoru. "Selective aerobic oxidation of allyl phenyl ether to methyl ketone by palladium–polyoxometalate hybrid catalysts". . . Retrieved 2020/09/03.