6-chloroquinazolin-2-amine

Base Information

• Chemical Name: 6-chloroquinazolin-2-amine
• CAS No.: 20028-71-1
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.609
• Hs Code.: 2933990090
• Mol file: 20028-71-1.mol

Synonyms:Quinazoline,2-amino-6-chloro- (8CI);

Chemical Property of 6-chloroquinazolin-2-amine

Chemical Property:

• Boiling Point: 403.4 °C at 760 mmHg
• PKA: 4.94±0.26(Predicted)
• Flash Point: 197.7 °C
• PSA: 51.80000
• Density: 1.445 g/cm³
• LogP: 2.44660

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloroquinazolin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloroquinazolin-2-amine

There total 2 articles about 6-chloroquinazolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 5-chloro-2-fluorobenzaldehyde (96515-79-6) → 6-chloroquinazolin-2-amine (20028-71-1)

Guidance literature:

In dimethyl amine; at 140 ℃; for 3h;

Reference yield:

→ 6-chloroquinazolin-2-amine (20028-71-1)

Guidance literature:

2-Amino-5-chlor-benzaldehyd, Guanidin*HCl;

DOI:10.1021/jm00311a007

Reference yield: 20.0%

6-chloroquinazolin-2-amine (20028-71-1) → 2,6-dichloroquinazoline (67092-18-6)

Guidance literature:

With tert-butyl nitrate; antimony(III) chloride; In 1,2-dichloro-ethane; at 60 ℃; for 3h; Inert atmosphere;

upstream raw materials:

guanidine carbonate

5-chloro-2-fluorobenzaldehyde

Downstream raw materials:

2,6-dichloroquinazoline

Refernces

• 1、 Horner,Henry. "Analogs of 3-amino-7-chloro-1,2,4-benzotriazine 1-oxide as antimalarial agents.". . p. 946 - 949. Retrieved 2007/10/07.