3-Phenylpyridin-2-ol

Base Information

• Chemical Name: 3-Phenylpyridin-2-ol
• CAS No.: 24228-13-5
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50376469
• Nikkaji Number: J3.242.948C
• Wikidata: Q82165395
• Mol file: 24228-13-5.mol

Synonyms:3-Phenylpyridin-2-ol;24228-13-5;2-HYDROXY-3-PHENYLPYRIDINE;3-phenyl-1H-pyridin-2-one;3-Phenyl-2-hydroxypyridine;Phenylpyridon;o-hydroxyphenylpyridine;3-Phenylpyridine-2-ol;3-phenyl-2-(1H)-pyridone;SCHEMBL149989;SCHEMBL8526461;DTXSID50376469;FLYJEBSUJDZJDE-UHFFFAOYSA-N;3-phenyl-1,2-dihydropyridin-2-one;MFCD04114134;AKOS006295408;DS-5659;CS-0156470;FT-0750594;O11050;A877990

Chemical Property of 3-Phenylpyridin-2-ol

Chemical Property:

• Vapor Pressure: 3.64E-07mmHg at 25°C
• Melting Point: 225-227 °C
• Refractive Index: 1.594
• Boiling Point: 417.1 °C at 760 mmHg
• PKA: 11.80±0.10(Predicted)
• Flash Point: 246.1 °C
• PSA: 33.12000
• Density: 1.158 g/cm³
• LogP: 2.45420
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 171.068413911
• Heavy Atom Count: 13
• Complexity: 259

Purity/Quality:

98%min ^*data from raw suppliers

2-HYDROXY-3-PHENYLPYRIDINE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CNC2=O

Technology Process of 3-Phenylpyridin-2-ol

There total 12 articles about 3-Phenylpyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ 2-hydroxy-3-phenylpyridine (24228-13-5)

Guidance literature:

With water; sodium acetate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,2-dichloro-ethane; at 60 - 85 ℃;

Reference yield: 58.0%

3-bromopyridin-2(1H)-one (13466-43-8) + phenylboronic acid (98-80-6) → 2-hydroxy-3-phenylpyridine (24228-13-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol402890m

Reference yield: 20.0%

diphenyl(trifluoromethanesulfonato)-λ3-iodane + 2-Pyridone (142-08-5,1199357-22-6) → 2-hydroxy-3-phenylpyridine (24228-13-5)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); potassium acetate; In acetonitrile; at 20 ℃; for 6h; Irradiation; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.3987/COM-16-13459

upstream raw materials:

1-tert-Butyl-3-phenyl-1H-pyridin-2-one

3-phenylpyridine

phenylacetylene

Pyrimidin-2(1H)-one

Downstream raw materials:

1,2-dihydro-1-<<5(4)-methyl-4(5)-imidazolyl>methyl>-2-oxo-3-phenylpyridine

(RS)-3-phenylpiperidin-2-one

4-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-morpholine-3,5-dione

3-{4-[4-(3-Phenyl-pyridin-2-yl)-piperazin-1-yl]-butyl}-1-thia-3-aza-spiro[4.4]nonane-2,4-dione

Refernces

• 1、 -. "A nitrogen oxide C2 - bit hydroxylated method (by machine translation)". Paragraph 0031; 0032; 0033; 0034; 0035; 0036-0038; 0123-0128. . Retrieved 2017/05/19.
• 2、 Chong, Eugene,Xue, Wei,Storr, Tim,Kennepohl, Pierre,Schafer, Laurel L.. "Pyridonate-Supported Titanium(III). Benzylamine as an Easy-To-Use Reductant". supporting information. p. 4941 - 4945. Retrieved 2015/11/09.