Technology Process of 1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanol
There total 10 articles about 1-(2-(2-fluorophenyl)-1,5-naphthyridin-3-yl)ethanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-(2-fluorophenyl)-1,5-naphthyridine-3-carbaldehyde; methylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
With
ammonium chloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 48 h / 100 °C / Inert atmosphere
2: selenium(IV) oxide / 1,4-dioxane / 16 h / Reflux
3: toluene-4-sulfonic acid / toluene / 12 h / 120 °C
4: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr
5: toluene-4-sulfonic acid / toluene / 4 h / 120 °C
6: diisobutylaluminium hydride / toluene; cyclohexane / 3 h / -78 - 0 °C
7: manganese(IV) oxide / 1,4-dioxane / 2 h / 20 °C
8: diethyl ether; tetrahydrofuran / 0 °C
With
manganese(IV) oxide; selenium(IV) oxide; hydrogen; diisobutylaluminium hydride; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 3102.97 Torr
2: toluene-4-sulfonic acid / toluene / 4 h / 120 °C
3: diisobutylaluminium hydride / toluene; cyclohexane / 3 h / -78 - 0 °C
4: manganese(IV) oxide / 1,4-dioxane / 2 h / 20 °C
5: diethyl ether; tetrahydrofuran / 0 °C
With
manganese(IV) oxide; hydrogen; diisobutylaluminium hydride;
palladium 10% on activated carbon; toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; cyclohexane; toluene;