3-(3-BROMO-PHENYL)-PROPIONALDEHYDE

Base Information

• Chemical Name: 3-(3-BROMO-PHENYL)-PROPIONALDEHYDE
• CAS No.: 210115-30-3
• Molecular Formula: C9H9 Br O
• Molecular Weight: 213.074
• Hs Code.: 2913000090
• Mol file: 210115-30-3.mol

Synonyms:Benzenepropanal,3-bromo;3-BROMO-BENZENEPROPANAL;

Chemical Property of 3-(3-BROMO-PHENYL)-PROPIONALDEHYDE

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Boiling Point: 267.764oC at 760 mmHg
• Flash Point: 77.314oC
• PSA: 17.07000
• Density: 1.399g/cm3
• LogP: 2.58060

Purity/Quality:

98%min ^*data from raw suppliers

3-(3-bromophenyl)propanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-BROMO-PHENYL)-PROPIONALDEHYDE

There total 8 articles about 3-(3-BROMO-PHENYL)-PROPIONALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

carbon monoxide (201230-82-2) + 3-bromostyrene (2039-86-3,25584-47-8) → 3-(3-bromophenyl)propanal (210115-30-3) + 2-(3-bromophenyl)propanal (59452-90-3)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium 4-dodecylbenzenesulfonate; Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate; In water; toluene; at 60 ℃; under 30003 Torr;

DOI:10.1016/j.cclet.2021.07.068

Reference yield:

3-(3-bromophenyl)-propan-1-ol (65537-54-4) → 3-(3-bromophenyl)propanal (210115-30-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane;

DOI:10.1016/j.tetlet.2014.12.129

Reference yield:

methyl 3-(3'-bromophenyl)-propionate (151583-29-8) → 3-(3-bromophenyl)propanal (210115-30-3)

Guidance literature:

With diisobutylaluminium hydride; In toluene; pentane; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.9b09373

upstream raw materials:

carbon monoxide

3-bromostyrene

3-(3-bromophenyl)-propan-1-ol

3-bromocinnamic acid

Downstream raw materials:

1-bromo-3-(but-3-en-1-yl)benzene

3-Bromocinnamic acid

(E)-3-(3-bromophenyl)acrylaldehyde

Refernces

• 1、 Nouaille, Augustin,Pannecoucke, Xavier,Poisson, Thomas,Couve-Bonnaire, Samuel. "Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis". supporting information. p. 2140 - 2147. Retrieved 2021/03/06.
• 2、 Nakashima, Ken-Ichi,Yamaguchi, Eiji,Noritake, Chihaya,Mitsugi, Yukari,Goto, Mayuki,Hirai, Takao,Abe, Naohito,Sakai, Eiji,Oyama, Masayoshi,Itoh, Akichika,Inoue, Makoto. "Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ-RXR". . p. 1526 - 1534. Retrieved 2020/05/19.