Technology Process of 8-(6-fluoropyridin-3-yl)-2-hydroxy-N-((5-(4-hydroxyphenyl)-1,3,4-thiadiazol-2-yl)methyl)octanamide
There total 7 articles about 8-(6-fluoropyridin-3-yl)-2-hydroxy-N-((5-(4-hydroxyphenyl)-1,3,4-thiadiazol-2-yl)methyl)octanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ethyl acetate; water / 24 h / 20 °C
2: hydrogenchloride / 18.08 h / -78 - -10 °C
3: triethylamine; pyridine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; screw-top tube
4: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 1034.32 Torr
5: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C
With
pyridine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride / 18.08 h / -78 - -10 °C
2: triethylamine; pyridine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; screw-top tube
3: hydrogen / palladium 10% on activated carbon / ethanol / 24 h / 1034.32 Torr
4: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 24 h / 20 °C
With
pyridine; hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide;
palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;