methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

Base Information

• Chemical Name: methyl 4,4-difluoro-1-methylcyclohexanecarboxylate
• CAS No.: 1360568-90-6
• Molecular Formula: C₉H₁₄F₂O₂
• Molecular Weight: 192.206
• Mol file: 1360568-90-6.mol

Synonyms:methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

Chemical Property of methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 4,4-difluoro-1-methylcyclohexanecarboxylate

There total 2 articles about methyl 4,4-difluoro-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4,4-difluorocyclohexane-1-carboxylate (121629-14-9) + methyl iodide (74-88-4) → methyl 4,4-difluoro-1-methylcyclohexanecarboxylate (1360568-90-6)

Guidance literature:

methyl 4,4-difluorocyclohexane-1-carboxylate; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at 20 ℃;

Reference yield:

4,4-difluorocyclohexanecarboxylic acid (122665-97-8) → methyl 4,4-difluoro-1-methylcyclohexanecarboxylate (1360568-90-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / 16 h / Reflux

2.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / -78 °C

2.2: 20 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; sulfuric acid; In tetrahydrofuran;

Reference yield:

methyl 4,4-difluoro-1-methylcyclohexanecarboxylate (1360568-90-6) → (4,4-difluoro-1-methylcyclohexyl)methanol (1360568-91-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

methyl 4,4-difluorocyclohexane-1-carboxylate

methyl iodide

4,4-difluorocyclohexanecarboxylic acid

Downstream raw materials:

(2S,3R,4R,5S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-methylphenyl)6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

(2S,3R₄R₅S,6R)-2-(3-(4-((4,4-difluoro-1-methylcyclohexyl)methoxy)benzyl)-4-fluorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(4,4-difluoro-1-methylcyclohexyl)methanol

Refernces