C₂₀H₂₇O₇PS

Base Information

• Chemical Name: C₂₀H₂₇O₇PS
• CAS No.: 1026696-12-7
• Molecular Formula: C₂₀H₂₇O₇PS
• Molecular Weight: 442.47
• Mol file: 1026696-12-7.mol

Synonyms:C₂₀H₂₇O₇PS

Chemical Property of C₂₀H₂₇O₇PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₇O₇PS

There total 4 articles about C₂₀H₂₇O₇PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenoxy-α-(diethoxyphosphinyl)benzenebutanesulfonic acid, cyclohexyl ester (157126-73-3) → C20H27O7PS (1026696-12-7)

Guidance literature:

3-Phenoxy-α-(diethoxyphosphinyl)benzenebutanesulfonic acid, cyclohexyl ester; With ammonium hydroxide; In methanol; at 60 ℃; for 3h;

In methanol;

DOI:10.1021/jm801023u

Reference yield:

3-Phenoxybenzaldehyde (39515-51-0) → C20H27O7PS (1026696-12-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

2.2: 1 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C

4.1: ammonium hydroxide / methanol / 3 h / 60 °C

4.2: DOWEX 50WX₈-200, H+ form

With ammonium hydroxide; sodium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

3-(3-phenoxyphenyl)propan-1-ol (106797-69-7) → C20H27O7PS (1026696-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

1.2: 1 h / 60 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C

3.1: ammonium hydroxide / methanol / 3 h / 60 °C

3.2: DOWEX 50WX₈-200, H+ form

With ammonium hydroxide; sodium hydride; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3-Phenoxy-α-(diethoxyphosphinyl)benzenebutanesulfonic acid, cyclohexyl ester

3-(3-phenoxyphenyl)propan-1-ol

3-Phenoxybenzaldehyde

1-(3-iodopropyl)-3-phenoxybenzene

Refernces

• 1、 Song, Yongcheng,Lin, Fu-Yang,Yin, Fenglin,Hensler, Mary,Poveda, Carlos A. Rodrígues,Mukkamala, Dushyant,Cao, Rong,Wang, Hong,Morita, Craig T.,Pacanowska, Dolores González,Nizet, Victor,Oldfield, Eric. "Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in staphylococcus aureus". experimental part. p. 976 - 988. Retrieved 2009/12/04.