4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE
• CAS No.: 99329-70-1
• Molecular Formula: C₁₁H₁₄ClN*ClH
• Molecular Weight: 232.153
• Hs Code.: 2933399090
• Mol file: 99329-70-1.mol

Synonyms:Piperidine,4-(3-chlorophenyl)-, hydrochloride (9CI);4-(3-Chlorophenyl)piperidinehydrochloride;

Chemical Property of 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000183mmHg at 25°C
• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 149.8 °C
• PSA: 12.03000
• LogP: 3.93780
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Chlorophenyl)piperidinehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE

There total 9 articles about 4-(3-CHLOROPHENYL)PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-(3-chloro-phenyl)-piperidine-1-carboxylic acid ethyl ester → 4-(3-chlorophenyl)piperidine hydrochloride (99329-70-1)

Guidance literature:

With hydrogenchloride; acetic acid; for 24h; Heating;

DOI:10.1002/jhet.5570360431

Reference yield:

4-(3-chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride → 4-(3-chlorophenyl)piperidine hydrochloride (99329-70-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 6h;

DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

4-(3-chlorophenyl)-1-methylpiperidine (764634-69-7) → 4-(3-chlorophenyl)piperidine hydrochloride (99329-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 4 h / 90 °C

2: 56 percent / conc. HCl; AcOH / 24 h / Heating

With hydrogenchloride; acetic acid; In toluene; 1: Condensation / 2: Hydrolysis;

DOI:10.1002/jhet.5570360431

upstream raw materials:

4-(3-chlorophenyl)-1-methylpiperidine

1-phenylmethyl-4-piperidone

1-benzyl-4-(3-chlorophenyl)piperidin-4-ol

1-benzyl-4-(3-chlorophenyl)-1,2,3,6-tetrahydropyridine

Refernces

• 1、 -. "GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY". Page/Page column 67. . Retrieved 2010/02/07.