Technology Process of C45H85FO3Si3
There total 25 articles about C45H85FO3Si3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
<3S-(1Z,3α,5β)>-<2-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>ethyl>diphenylphosphine Oxide;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - -70 ℃;
for 0.416667h;
(1R,3aR,4S,7aR)-1-[1,5-dimethyl-1-(4-methyl-4-trimethylsilanyloxy-pentyl)-5-trimethylsilanyloxy-hexyl]-7a-methyl-octahydro-inden-4-one;
In
tetrahydrofuran;
at -40 ℃;
for 5h;
- Guidance literature:
-
<3S-(1Z,3α,5β)>-<2-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>ethyl>diphenylphosphine Oxide;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - -70 ℃;
for 0.416667h;
(1R,3aR,4S,7aR)-1-[1,5-dimethyl-1-(4-methyl-4-trimethylsilanyloxy-pentyl)-5-trimethylsilanyloxy-hexyl]-7a-methyl-octahydro-inden-4-one;
In
tetrahydrofuran;
at -40 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran; toluene / 1 h / 5 - 20 °C
1.2: 4 h / -15 - -10 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr
3.1: diethyl ether / 3.5 h / 0 - 20 °C
3.2: 0 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 48 h / 70 °C
5.1: dipyridinium dichromate; Celite / dichloromethane / 5 h / 20 °C
6.1: dichloromethane / 2.5 h / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 0.42 h / -78 - -70 °C
7.2: 5 h / -40 °C
With
dipyridinium dichromate; n-butyllithium; Celite; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene;