Technology Process of (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate
There total 15 articles about (S)-(9H-fluoren-9-yl)methyl 8-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethylcarbamoyl)-1,4-dioxaspiro[4.5]decan-8-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-2-amino-3-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)propanenitrile;
With
4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
In
dichloromethane;
at 0 ℃;
for 0.5h;
8-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-dioxaspiro[4,5]decane-8-carboxylic acid;
In
dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / Reflux
2.1: sodium hydrogencarbonate / acetone / 20 °C
3.1: ammonia; methanol / 0.25 h / -50 - 20 °C
4.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
5.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C
6.1: formic acid / 4 h / 40 °C
7.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C
7.2: 12 h / 20 °C
With
methanol; formic acid; thionyl chloride; ammonia; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic anhydride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
dichloromethane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: sodium acetate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / Inert atmosphere; Reflux
3.1: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C
4.1: formic acid / 4 h / 40 °C
5.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0.5 h / 0 °C
5.2: 12 h / 20 °C
With
formic acid; sodium acetate; sodium carbonate; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride;
tetrakis(triphenylphosphine) palladium(0); palladium bis[bis(diphenylphosphino)ferrocene] dichloride;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
