2-Pyrimidinecarboximidamide,N-hydroxy-

Base Information

• Chemical Name: 2-Pyrimidinecarboximidamide,N-hydroxy-
• CAS No.: 90993-49-0
• Molecular Formula: C5H6 N4 O
• Molecular Weight: 138.129
• Mol file: 90993-49-0.mol

Synonyms:2-Pyrimidinecarboxamidoxime(7CI); N'-Hydroxypyrimidine-2-carboximidamide

Chemical Property of 2-Pyrimidinecarboximidamide,N-hydroxy-

Chemical Property:

• Melting Point: 230-235℃
• Boiling Point: 410.9°Cat760mmHg
• Flash Point: 202.3°C
• PSA: 84.39000
• Density: 1.49g/cm³
• LogP: 0.27140

Purity/Quality:

98%min ^*data from raw suppliers

N''-Hydroxypyrimidine-2-carboximidamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinecarboximidamide,N-hydroxy-

There total 9 articles about 2-Pyrimidinecarboximidamide,N-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-cyanopyrimidine (14080-23-0) → pyrimidine-2-carboxamide oxime (90993-49-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; for 2h; Reflux;

DOI:10.1002/aoc.4796

Reference yield: 77.0%

2-cyanopyrimidine (14080-23-0) → (Z)-N'-hydroxy-pyrimidine-2-carboxamidine (90993-49-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In water; at 70 ℃; for 14h;

DOI:10.1021/jm400221d

Reference yield: 77.0%

→ pyrimidine-2-carboxamide oxime (90993-49-0)

Guidance literature:

upstream raw materials:

2-cyanopyrimidine

pyrimidine-2-carboxamide

5-bromo-pyrimidine-2-carboxylic acid amide

5-bromopyrimidine-2-carboxylic acid methyl ester

Downstream raw materials:

N-({2-[5-(4-fluorobenzyl)-3-pyridin-4-yl-1H-pyrazol-1-yl]acetyl}oxy)pyrimidine-2-carboximidamide

N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyrimidin-2-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide

Refernces

• 1、 Yin, Xiu-Ju,Zhu, Long-Guan. "Structural variation from trinuclears to 1D chains: Syntheses, structures and properties". . . Retrieved 2019.
• 2、 -. "CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 1427. . Retrieved 2018/04/17.