(2-Methylpyridin-4-yl)methanamine

Base Information

• Chemical Name: (2-Methylpyridin-4-yl)methanamine
• CAS No.: 94413-70-4
• Molecular Formula: C7H10 N2
• Molecular Weight: 122.17
• Hs Code.: 29333990
• European Community (EC) Number: 809-756-3
• DSSTox Substance ID: DTXSID10607145
• Wikidata: Q82506100
• Mol file: 94413-70-4.mol

Synonyms:(2-Methylpyridin-4-yl)methanamine;94413-70-4;4-(Aminomethyl)-2-methylpyridine;4-Pyridinemethanamine, 2-methyl-;1-(2-METHYLPYRIDIN-4-YL)METHANAMINE;4-Aminomethyl-2-methylpyridine;MFCD06637475;SCHEMBL668247;DTXSID10607145;AKOS006282536;AB25370;AM804587;CS-16806;SY035341;DB-104735;1-(2-METHYL-4-PYRIDINYL)METHANAMINE;CS-0104071;(2-Methylpyridin-4-yl)methanamine, AldrichCPR;EN300-227178;H10984;A859432

Chemical Property of (2-Methylpyridin-4-yl)methanamine

Chemical Property:

• Vapor Pressure: 0.111mmHg at 25°C
• Refractive Index: 1.545
• Boiling Point: 220.8°C at 760 mmHg
• PKA: 7.84±0.29(Predicted)
• Flash Point: 108°C
• PSA: 38.91000
• Density: 1.027g/cm³
• LogP: 1.54900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%Min ^*data from raw suppliers

4-Aminomethyl-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1)CN

Technology Process of (2-Methylpyridin-4-yl)methanamine

There total 6 articles about (2-Methylpyridin-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 1-(2-methylpyridin-4-yl)methanamine (94413-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: chloroform; phosphorus (III)-chloride

3: 180 °C

4: palladium/charcoal; aq.-ethanolic HCl / Hydrogenation

With hydrogenchloride; palladium on activated charcoal; chloroform; phosphorus trichloride;

Reference yield:

2-methyl-4-cyanopyridine (2214-53-1) → 1-(2-methylpyridin-4-yl)methanamine (94413-70-4)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; Hydrogenation;

Reference yield:

2-chloro-4-pyridinenitrile (33252-30-1) → 1-(2-methylpyridin-4-yl)methanamine (94413-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; 1,4-dioxane / 10 h / 130 °C / Inert atmosphere

2: ammonia; hydrogen / methanol / 12 h / 40 °C / 2585.81 Torr / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; In 1,4-dioxane; methanol; toluene;

upstream raw materials:

2-methyl-4-cyanopyridine

4-bromo-2-methylpyridine

2-methyl-4-nitro-pyridine

2-methyl-4-nitropyridine N-oxide

Downstream raw materials:

8-methoxy-2-(2-methyl-pyridin-4-ylmethyl)-1-oxo-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

2-((2-methylpyridin-4-yl)methyl)-4-(3,4,5-trimethoxyphenyl)-8-((pyrimidin-2-yl)methoxy)-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester

Refernces

• 1、 -. "NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION". Page/Page column 131. . Retrieved 2016/12/01.
• 2、 OCHIAI,SUZUKI. "Polarization of heterocyclic rings having aromatic characteristics. CV. 4-Substituted 2-picoline derivatives.". . p. 147 - 149. Retrieved 2007/10/04.