prop-2-en-1-yl 1-methyl-2-oxocyclohexanecarboxylate

Base Information

• Chemical Name: prop-2-en-1-yl 1-methyl-2-oxocyclohexanecarboxylate
• CAS No.: 7770-41-4
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Mol file: 7770-41-4.mol

Synonyms:

Chemical Property of prop-2-en-1-yl 1-methyl-2-oxocyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 0.0036mmHg at 25°C
• Boiling Point: 281.3°Cat760mmHg
• Flash Point: 119.5°C
• Density: 1.048g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of prop-2-en-1-yl 1-methyl-2-oxocyclohexanecarboxylate

There total 6 articles about prop-2-en-1-yl 1-methyl-2-oxocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pimelic acid diallyl ester (91906-66-0) + methyl iodide (74-88-4) → 1-methyl-2-oxocyclohexanecarboxylic acid 2-propenyl ester (7770-41-4)

Guidance literature:

pimelic acid diallyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 40 ℃; for 10h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 40 ℃; for 15h; Inert atmosphere;

DOI:10.15227/orgsyn.086.0194

Reference yield: 77.0%

allyl 2-oxocyclohexane-1-carboxylate (5453-93-0) + methyl iodide (74-88-4) → 1-methyl-2-oxocyclohexanecarboxylic acid 2-propenyl ester (7770-41-4)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1055/s-1987-28145

Reference yield: 62.0%

pimelic acid diallyl ester (91906-66-0) + allyl alcohol (107-18-6) → 1-methyl-2-oxocyclohexanecarboxylic acid 2-propenyl ester (7770-41-4)

Guidance literature:

allyl alcohol; With sodium hydride; In toluene; Inert atmosphere;

pimelic acid diallyl ester; In toluene; at 95 ℃; for 1h; Inert atmosphere;

methyl halide; In tetrahydrofuran; at 50 ℃; for 2.5h;

DOI:10.1002/chem.201003383

upstream raw materials:

allyl 2-oxocyclohexane-1-carboxylate

methyl iodide

2-(methoxycarbonyl)cyclohexanone

pimelic acid diallyl ester

Downstream raw materials:

<2'-methyl-2'-(prop-2''-enyl)cyclohexylidene>propanedinitrile

(S)-2-methylcyclohexanone

(R)-2-methylcyclohexanone

2-(1-Hydroxy-hexyl)-2-methyl-cyclohexanone

Refernces

• 1、 -. "METHODS AND COMPOSITIONS FOR TERPENOID SYNTHESIS". Paragraph 00107; 00109. . Retrieved 2018/04/13.
• 2、 Lahtigui, Ouidad,Emmetiere, Fabien,Zhang, Wei,Jirmo, Liban,Toledo-Roy, Samira,Hershberger, John C.,Macho, Jocelyn M.,Grenning, Alexander J.. "Assembly of Terpenoid Cores by a Simple, Tunable Strategy". supporting information. p. 15792 - 15796. Retrieved 2016/12/16.