C₄₉H₄₈F₂O₆

Base Information

• Chemical Name: C₄₉H₄₈F₂O₆
• CAS No.: 1413373-42-8
• Molecular Formula: C₄₉H₄₈F₂O₆
• Molecular Weight: 770.913
• Mol file: 1413373-42-8.mol

Synonyms:C₄₉H₄₈F₂O₆

Chemical Property of C₄₉H₄₈F₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₄₈F₂O₆

There total 21 articles about C₄₉H₄₈F₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

C49H48O7 (1413373-40-6) → C49H48F2O6 (1413373-42-8)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

2,3,4,6-Tetra-O-benzyl-D-glucopyranose (4291-69-4,6386-24-9,6564-72-3,59531-24-7,69257-52-9,78184-89-1,78609-16-2,78609-17-3,78609-18-4,96553-53-6,104111-61-7,131347-08-5,4132-28-9) → C49H48F2O6 (1413373-42-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: acetic anhydride; dimethyl sulfoxide / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C

2.3: cooling with ice

3.1: sodium tetrahydroborate / tetrahydrofuran / 20 °C

4.1: trifluoroacetic anhydride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

4.2: -78 - 0 °C

5.1: potassium carbonate / 18-crown-6 ether / toluene / 20 °C

6.1: L-Selectride / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

6.2: 0.25 h

7.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 0.5 h / 0 °C / Inert atmosphere

8.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

8.2: 3 h / 0 - 20 °C

9.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C

10.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; tributylphosphine; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; acetic anhydride; L-Selectride; potassium carbonate; Dess-Martin periodane; dimethyl sulfoxide; trifluoroacetic anhydride; 1,1'-azodicarbonyl-dipiperidine; 18-crown-6 ether; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; toluene; 7.1: Mitsunobu reaction;

Reference yield:

methoxybenzene (100-66-3) → C49H48F2O6 (1413373-42-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyrographite; methanesulfonic acid / 12 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 22502.3 Torr

3.1: 1,1'-azodicarbonyl-dipiperidine; tributylphosphine / toluene / 0.5 h / 0 °C / Inert atmosphere

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C

4.2: 3 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C

6.1: diethylamino-sulfur trifluoride / dichloromethane / 20 °C / Inert atmosphere

With methanesulfonic acid; tributylphosphine; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; hydrogen; pyrographite; Dess-Martin periodane; 1,1'-azodicarbonyl-dipiperidine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; toluene; 3.1: Mitsunobu reaction;

upstream raw materials:

ortho-anisaldehyde

methoxybenzene

2,3,4,6-Tetra-O-benzyl-D-glucopyranose

salicylic acid

Downstream raw materials:

C₂₁H₂₄F₂O₆

Refernces