N-[4-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)PHENYL]GLYCINE

Base Information

• Chemical Name: N-[4-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)PHENYL]GLYCINE
• CAS No.: 872728-82-0
• Molecular Formula: C10H9N3O4
• Molecular Weight: 235.199
• Hs Code.: 2934999090
• Mol file: 872728-82-0.mol

Synonyms:2-[4-(5-oxo-2H-1,2,4-oxadiazol-3-yl)anilino]acetic acid

Chemical Property of N-[4-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)PHENYL]GLYCINE

Chemical Property:

• Appearance/Colour: White solid
• Boiling Point: 460.358 °C at 760 mmHg
• Flash Point: 232.217 °C
• PSA: 108.22000
• Density: 1.578 g/cm³
• LogP: 0.59940
• Storage Temp.: 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

2-((4-(5-Oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)amino)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)PHENYL]GLYCINE

There total 1 articles about N-[4-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)PHENYL]GLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[4-(5-oxo-1,2,4-oxadiazol-3-yl)phenylamino]acetic acid ethyl ester (872728-83-1) → 2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid (872728-82-0)

Guidance literature:

2-[4-(5-oxo-1,2,4-oxadiazol-3-yl)phenylamino]acetic acid ethyl ester; With sodium hydroxide; water; at 20 - 60 ℃; for 1h; pH=12.5;

With hydrogenchloride; at 0 - 60 ℃; pH=5;

Reference yield: 85.0%

2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid (872728-82-0) + ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate (212322-56-0) → 1-methyl-2-[N-[4-(1,2,4-oxadiazol-5-one-3-yl)phenyl]-amino-methyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide (872728-84-2)

Guidance literature:

2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 1.5h;

With acetic acid; at 90 ℃; Product distribution / selectivity;

Reference yield: 75.0%

2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid (872728-82-0) + acetic acid (64-19-7,77671-22-8) + ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate (212322-56-0) → 1-methyl-2-[N-[4-(1,2,4-oxadiazol-5-on-3-yl)phenyl]aminomethyl]benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide diacetate

Guidance literature:

2-[4-(1,2,4-oxadiazol-5-one-3-yl)-phenylamino]-acetic acid; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 19.5h;

acetic acid; In tetrahydrofuran; for 1h; Heating / reflux;

upstream raw materials:

2-[4-(5-oxo-1,2,4-oxadiazol-3-yl)phenylamino]acetic acid ethyl ester

Downstream raw materials:

1-methyl-2-[N-[4-(1,2,4-oxadiazol-5-one-3-yl)phenyl]-amino-methyl]-benzimidazol-5-yl-carboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

Refernces

• 1、 -. "IMPROVED PROCESS FOR THE PREPARATION OF THE SALTS OF 4-(BENZIMIDAZOLYLMETHYLAMINO)-BENZAMIDES". Page/Page column 17. . Retrieved 2010/11/27.