3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene

Base Information

• Chemical Name: 3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene
• CAS No.: 872131-45-8
• Molecular Formula: C₂₂H₁₈O₃
• Molecular Weight: 330.383
• Mol file: 872131-45-8.mol

Synonyms:1-(5-Benzyloxy-2-hydroxy-phenyl)-3-phenyl-propenone;3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene;5benzyloxy-2hydroxychalcone;(2E)-1-[2-Hydroxy-4-(phenylmethoxy)phenyl]-3-phenyl-2-propen-1-one

Chemical Property of 3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 90-92°C
• Refractive Index: 1.655
• Boiling Point: 545.598°C at 760 mmHg
• PKA: 7.26±0.35(Predicted)
• Flash Point: 194.794°C
• PSA: 46.53000
• Density: 1.21g/cm³
• LogP: 4.86730
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3-Oxo-1-phenyl-3-(2’-hydroxy-5-benzyloxyphenyl)propene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Oxo-1-phenyl-3-(2’-hydroxy-5-benzyloxyphenyl)propene (cas# 872131-45-8) is a compound useful in organic synthesis.

Technology Process of 3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene

There total 8 articles about 3-Oxo-1-phenyl-3-(2hydroxy-5-benzyloxyphenyl)propene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) + benzaldehyde (100-52-7) → (2E)-1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenylprop-2-en-1-one (24532-21-6,872131-45-8)

Guidance literature:

With potassium hydroxide; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

DOI:10.1021/acs.jpca.6b03290

Reference yield: 84.0%

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) + benzaldehyde (100-52-7) → 1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenyl-2-propen-1-one (24532-21-6,872131-45-8)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 10h;

DOI:10.1039/c5ra13912k

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → (2E)-1-[4-(benzyloxy)-2-hydroxyphenyl]-3-phenylprop-2-en-1-one (24532-21-6,872131-45-8)

Guidance literature:

upstream raw materials:

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone

benzaldehyde

2',4'-dihydroxy-4-acetophenone

benzyl chloride

Downstream raw materials:

7-(benzyloxy)-2-phenyl-4H-chromen-4-one

C₂₅H₂₂O₃

C₂₅H₂₂Br₂O₃

Refernces

• 1、 Serdiuk, Illia E.,Roshal, Alexander D.,B?azejowski, Jerzy. "Origin of Spectral Features and Acid-Base Properties of 3,7-Dihydroxyflavone and Its Monofunctional Derivatives in the Ground and Excited States". . p. 4325 - 4337. Retrieved 2016/07/11.
• 2、 Serdiuk,Roshal,B?a?ejowski. "Quantum-chemical analysis of the Algar-Flynn-Oyamada reaction mechanism". . p. 396 - 403. Retrieved 2014/08/05.