6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid

Base Information

• Chemical Name: 6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid
• CAS No.: 871126-14-6
• Molecular Formula: C₈H₉BBrFO₃
• Molecular Weight: 262.871
• Hs Code.: 2931900090
• Mol file: 871126-14-6.mol

Synonyms:6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid;Boronic acid, B-(6-bromo-3-ethoxy-2-fluorophenyl)-;2-Fluoro-3-ethoxy-6-bromophenylboronic acid;6-Bromo-3-ethoxy-2-fluorophenylboronic acid;6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid 98%;

Chemical Property of 6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid

Chemical Property:

• Boiling Point: 386.4 °C at 760 mmHg
• Flash Point: 187.5 °C
• PSA: 49.69000
• Density: 1.6 g/cm³
• LogP: 0.66670

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-3-ethoxy-2-fluorophenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid

There total 2 articles about 6-Bromo-3-ethoxy-2-fluorobenzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

hydrogenchloride (7647-01-0,15364-23-5) + Trimethyl borate (121-43-7,63156-11-6) + water (7732-18-5) + 3-fluoro-4-ethoxy bromobenzene (115467-08-8) → (6-bromo-3-ethoxy-2-fluorophenyl)boronic acid (871126-14-6)

Guidance literature:

3-fluoro-4-ethoxy bromobenzene; With lithium diisopropyl amide; In tetrahydrofuran; Petroleum ether; at -78 ℃; for 0.5h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

hydrogenchloride; water; In tetrahydrofuran; at -78 - -20 ℃; for 2h; Inert atmosphere;

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + water (7732-18-5) + 3-fluoro-4-ethoxy bromobenzene (115467-08-8) → (6-bromo-3-ethoxy-2-fluorophenyl)boronic acid (871126-14-6)

Guidance literature:

3-fluoro-4-ethoxy bromobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -70 - -60 ℃; for 2h;

Trimethyl borate; water; With hydrogenchloride; In tetrahydrofuran; at -80 - -70 ℃;

upstream raw materials:

hydrogenchloride

Trimethyl borate

water

3-fluoro-4-ethoxy bromobenzene

Refernces

• 1、 -. "Liquid crystal compound with negative dielectric anisotropy as well as preparation method and application thereof". Paragraph 0059; 0062-0063. . Retrieved 2021/05/08.