3-Pyridinecarbonitrile, 2-amino-5-chloro-

Base Information

• Chemical Name: 3-Pyridinecarbonitrile, 2-amino-5-chloro-
• CAS No.: 869557-28-8
• Molecular Formula: C6H4 Cl N3
• Molecular Weight: 153.571
• Hs Code.: 2933399090
• Mol file: 869557-28-8.mol

Synonyms:2-Amino-5-chloronicotinonitrile

Chemical Property of 3-Pyridinecarbonitrile, 2-amino-5-chloro-

Chemical Property:

• PSA: 63.43000
• LogP: 1.11898
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Amino-5-chloronicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile, 2-amino-5-chloro-

There total 2 articles about 3-Pyridinecarbonitrile, 2-amino-5-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

zinc(II) cyanide (557-21-1) + 2-amino-3-bromo-5-chloropyridine (26163-03-1) → 2-amino-5-chloropyridine-3-carbonitrile (869557-28-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 5h; Further stages;

Reference yield:

dicyanozinc (557-21-1) + 2-amino-3-bromo-5-chloropyridine (26163-03-1) → 2-amino-5-chloropyridine-3-carbonitrile (869557-28-8)

Guidance literature:

1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); at 120 ℃; for 0.5h; Microwave heating;

upstream raw materials:

dicyanozinc

2-amino-3-bromo-5-chloropyridine

zinc(II) cyanide

Refernces

• 1、 -. "NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES". Paragraph 0623-0625. . Retrieved 2014/10/29.