Technology Process of (trans-4-(2-(benzyloxy)ethyl)cyclohexyl)methanol
There total 7 articles about (trans-4-(2-(benzyloxy)ethyl)cyclohexyl)methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
((2-(4-methylenecyclohexyl)ethoxy)methyl)benzene;
With
diborane-dimethylsulfide complex;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
1.2: 3.17 h / 0 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 1810.07 Torr
3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
4.2: 20 °C
5.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C
6.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere
6.2: -40 - 20 °C
7.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
7.2: 2.5 h / 0 - 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; diborane-dimethylsulfide complex; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride;
In
tetrahydrofuran; methanol; diethyl ether; water; acetonitrile; mineral oil;
6.1: |Wittig Olefination / 6.2: |Wittig Olefination;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.58 h / 0 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.17 h / 0 - 20 °C
2.2: 20 °C
3.1: hydrogenchloride / water; acetonitrile / 2 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere
4.2: -40 - 20 °C
5.1: diborane-dimethylsulfide complex / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5.2: 2.5 h / 0 - 20 °C
With
hydrogenchloride; lithium aluminium tetrahydride; diborane-dimethylsulfide complex; potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; diethyl ether; water; acetonitrile; mineral oil;
4.1: |Wittig Olefination / 4.2: |Wittig Olefination;