8-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE

Base Information

• Chemical Name: 8-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE
• CAS No.: 868362-18-9
• Molecular Formula: C₆H₄BrN₃
• Molecular Weight: 198.022
• Hs Code.: 2933990090
• Mol file: 868362-18-9.mol

Synonyms:8-Bromo-[1,2,4]triazolo[1,5-a]pyridine;

Chemical Property of 8-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE

Chemical Property:

• Melting Point: 150-152°C
• Refractive Index: 1.751
• PKA: 1.28±0.30(Predicted)
• PSA: 30.19000
• Density: 1.891 g/cm³
• LogP: 1.49180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo[1,2,4]triazolo[1,5-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE

There total 2 articles about 8-BROMO-[1,2,4]TRIAZOLO[1,5-A]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(3-bromopyrid-2-yl)formamidoxime → 8-bromo-[1,2,4]triazolo[1,5-a]pyridine (868362-18-9)

Guidance literature:

With trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.200500247

Reference yield:

2-Amino-3-bromopyridine (13534-99-1) → 8-bromo-[1,2,4]triazolo[1,5-a]pyridine (868362-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: propan-2-ol / Heating

1.2: 74 percent / hydroxylamine hydrochloride / propan-2-ol / 50 °C

2.1: 86 percent / trifluoroacetic anhydride / tetrahydrofuran / 20 °C

With trifluoroacetic anhydride; In tetrahydrofuran; isopropyl alcohol;

DOI:10.1002/ejoc.200500247

upstream raw materials:

2-Amino-3-bromopyridine

Refernces