4-Amino-2-phenylphenol

Base Information

• Chemical Name: 4-Amino-2-phenylphenol
• CAS No.: 19434-42-5
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2922199090
• European Community (EC) Number: 827-413-6
• NSC Number: 409777
• DSSTox Substance ID: DTXSID70173058
• Nikkaji Number: J1.608.436K
• Wikidata: Q83043161
• Mol file: 19434-42-5.mol

Synonyms:19434-42-5;4-AMINO-2-PHENYLPHENOL;5-Amino-[1,1'-biphenyl]-2-ol;[1,1'-Biphenyl]-2-ol, 5-amino-;(1,1'-Biphenyl)-2-ol, 5-amino-;5-amino[1,1'-biphenyl]-2-ol;5-Amino-(1,1'-biphenyl)-2-ol;AI3-16508;[1,1'-Biphenyl]-2-ol,5-amino-;NSC409777;5-Aminobiphenyl-2-ol;Oc1ccc(N)cc1c2ccccc2;5-Amino-biphenyl-2-ol;4-amino-2-phenyl-phenol;2-hydroxy-5-aminobiphenyl;SCHEMBL900806;DTXSID70173058;OUIITAOCYATDMY-UHFFFAOYSA-N;AKOS006291111;NSC 409777;NSC-409777;BS-52017;CS-0230849;EC-000.1688;E76974;EN300-105846;Z1198177221

Chemical Property of 4-Amino-2-phenylphenol

Chemical Property:

• Melting Point: 201 °C
• Boiling Point: 384.7 °C at 760 mmHg
• PKA: 10.25±0.18(Predicted)
• Flash Point: 186.4 °C
• PSA: 46.25000
• Density: 1.191 g/cm³
• LogP: 3.22260
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 185.084063974
• Heavy Atom Count: 14
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

4-AMINO-2-PHENYLPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C=CC(=C2)N)O
• Uses: 4-Amino-2-phenylphenol is phenylphenol derivative with herbicidal and fungicidal activity.

Technology Process of 4-Amino-2-phenylphenol

There total 14 articles about 4-Amino-2-phenylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-nitrobiphenyl-2-ol (4291-29-6) → 4-amino-6-phenylphenol (19434-42-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 2068.59 Torr;

DOI:10.1021/ja038016n

Reference yield: 82.0%

2-chlorophenyl-2,5-cyclohexadiene-1,4-dione 4-oxime (36697-36-6) → 4-amino-6-phenylphenol (19434-42-5)

Guidance literature:

With sodium dithionite; sodium carbonate; at 35 ℃; for 5h;

DOI:10.1021/jm00156a009

Reference yield:

4-phenoxyanilin (139-59-3) → 4-Phenylphenol (92-69-3) + 4-amino-6-phenylphenol (19434-42-5) + 4-amino-phenol (123-30-8) + 4-phenylalanine (92-67-1)

Guidance literature:

In ethanol; for 0.3h; Ambient temperature; Irradiation;

DOI:10.1021/jo9517196

upstream raw materials:

5-nitrobiphenyl-2-ol

5-Nitroso-biphenyl-2-ol

2-phenyl-4-phenylazophenol

4-diazobenzenesulfonic acid

Downstream raw materials:

5-chloro-biphenyl-2-ol

N-Benzoyl-2-hydroxy-5-aminobiphenyl

6-ethoxy-biphenyl-3-ylamine

5-chloro-2-methoxy-1,1'-biphenyl

Refernces

• 1、 Zhang, Yuan Yuan,Zeng, Xing Yan,Nie, Kui,Zhong, Zhi Cheng,Wang, Yu Liang,Wang, Yu Zhong. "Synthesis and biological evaluation of ethyl 6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylates against Eimeria tenella". scheme or table. p. 426 - 428. Retrieved 2010/12/25.
• 2、 Dickerson, Tobin J.,Tremblay, Martin R.,Hoffman, Timothy Z.,Ruiz, Diana I.,Janda, Kim D.. "Catalysis of the Photo-Fries Reaction: Antibody-Mediated Stabilization of High Energy States". . p. 15395 - 15401. Retrieved 2007/10/03.