Technology Process of (S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid
There total 12 articles about (S)-4-((2-carbamoyl-5-chloro-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indol-7-yl)amino)-4-oxobutanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
at 110 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 1 h / 20 - 100 °C
2.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C
2.2: 15 h / 45 - 50 °C
3.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice
4.1: triethylamine / dichloromethane / 4 h
5.1: ammonium chloride; iron / ethanol / 80 - 85 °C
6.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube
7.1: toluene / 2 h / 110 °C
With
ammonia; ammonium formate; tetra(n-butyl)ammonium hydrogensulfate; iron; ammonium chloride; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; water; isopropyl alcohol; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale
1.2: 0.5 h / -5 - 0 °C
2.1: Polyphosphoric acid (PPA) / 110 °C
3.1: acetic anhydride; sulfuric acid / 0 - 20 °C
3.2: 0 - 20 °C
4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C
5.1: triethylamine / dichloromethane / 4 h
6.1: ammonium chloride; iron / ethanol / 80 - 85 °C
7.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube
8.1: toluene / 2 h / 110 °C
With
oxalyl dichloride; sulfuric acid; ammonia; acetic anhydride; iron; ammonium chloride; triethylamine; potassium hydroxide;
N,N-dimethyl-formamide;
In
ethanol; dichloromethane; water; isopropyl alcohol; toluene;