2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 857035-29-1
• Molecular Formula: C10H9 Cl N2 O2
• Molecular Weight: 224.647
• Mol file: 857035-29-1.mol

Synonyms:1H-Benzimidazole-5-carboxylicacid, 2-chloro-, ethyl ester (9CI); 2-Chloro-3H-benzimidazole-5-carboxylic AcidEthyl Ester

Chemical Property of 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 54.98000
• LogP: 2.39300
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-chloro-1H-benzo[d]imidazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER

There total 2 articles about 2-CHLORO-3H-BENZIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester (634602-84-9) → 2-chloro-3H-benzoimidazole-5-carboxylic acid ethyl ester (857035-29-1)

Guidance literature:

With hydrogenchloride; trichlorophosphate; In water; at 100 - 120 ℃; for 6h;

Reference yield:

2-oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid ethyl ester → ethyl 2-chloro-1H-benzimidazole-5-carboxylate (857035-29-1)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃;

DOI:10.1016/j.bmcl.2008.08.018

Reference yield: 95.0%

2-chloro-3H-benzoimidazole-5-carboxylic acid ethyl ester (857035-29-1) → (2-chloro-3H-benzoimidazol-5-yl)methanol (857070-66-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃; for 3h;

DOI:10.1021/jm701284j

upstream raw materials:

2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester

Downstream raw materials:

2-(1-benzylpiperidin-4-ylamino)-3H-benzoimidazole-5-carboxylic acid ethyl ester

[2-(3-morpholin-4-ylpropylamino)-3H-benzoimidazol-5-yl]methanol

(2-chloro-3H-benzoimidazol-5-yl)methanol

2-phenethylamino-3H-benzoimidazole-5-carboxylic acid ethyl ester

Refernces

• 1、 Ogino, Yoshio,Ohtake, Norikazu,Nagae, Yoshikazu,Matsuda, Kenji,Moriya, Minoru,Suga, Takuya,Ishikawa, Makoto,Kanesaka, Maki,Mitobe, Yuko,Ito, Junko,Kanno, Tetsuya,Ishihara, Akane,Iwaasa, Hisashi,Ohe, Tomoyuki,Kanatani, Akio,Fukami, Takehiro. "Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4′-piperidin]-1′-yl}benzimidazole derivatives". scheme or table. p. 5010 - 5014. Retrieved 2009/05/07.
• 2、 -. "MORPHOLINYL CONTAINING BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION". Page/Page column 40-41; 61-62. . Retrieved 2010/02/12.