[402960-19-4],C9H18N2O2, 186.40

Base Information

• Chemical Name: [402960-19-4],C9H18N2O2, 186.40
• CAS No.: 850252-34-5
• Molecular Formula: C9H18 N2 O2 . Cl H
• Molecular Weight: 222.715
• Hs Code.: 2924299090
• Mol file: 850252-34-5.mol

Synonyms:Hexanamide,3-amino-N-cyclopropyl-2-hydroxy-, monohydrochloride, (3S)- (9CI)

Chemical Property of [402960-19-4],C9H18N2O2, 186.40

Chemical Property:

• PSA: 0.00000
• LogP: 12.86140
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamidehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [402960-19-4],C9H18N2O2, 186.40

There total 6 articles about [402960-19-4],C9H18N2O2, 186.40 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide (856707-39-6) → (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride (850252-34-5,1166397-39-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

acetic acid (2S)-2-tert-butoxycarbonylamino-1-cyclopropylcarbamoylpentyl ester (856707-38-5) → (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride (850252-34-5,1166397-39-2)

Guidance literature:

acetic acid (2S)-2-tert-butoxycarbonylamino-1-cyclopropylcarbamoylpentyl ester; With water; lithium hydroxide; In tetrahydrofuran;

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/ml9000276

Reference yield:

(2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide (944716-71-6) → (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride (850252-34-5,1166397-39-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2009.02.079

upstream raw materials:

(3S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide

(2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide

acetic acid (2S)-2-tert-butoxycarbonylamino-1-cyclopropylcarbamoylpentyl ester

N-tert-butoxycarbonyl-L-norvaline

Downstream raw materials:

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

Refernces

• 1、 Arasappan, Ashok,Bennett, Frank,Bogen, Stephane L.,Venkatraman, Srikanth,Blackman, Melissa,Chen, Kevin X.,Hendrata, Siska,Huang, Yuhua,Huelgas, Regina M.,Nair, Latha,Padilla, Angela I.,Pan, Weidong,Pike, Russell,Pinto, Patrick,Ruan, Sumei,Sannigrahi, Mousumi,Velazquez, Francisco,Vibulbhan, Bancha,Wu, Wanli,Yang, Weiying,Saksena, Anil K.,Girijavallabhan, Viyyoor,Shih, Neng-Yang,Kong, Jianshe,Meng, Tao,Jin, Yan,Wong, Jesse,McNamkra, Paul,Prongay, Andrew,Madison, Vincent,Piwinski, John J.,Cheng, Kuo-Chi,Morrison, Richard,Malcolm, Bruce,Tong, Xiao,Ralston, Robert,Njoroge, F. George. "Discovery of narlaprevir (SCH 900518): A potent, second generation HCV NS3 serine protease inhibitor". scheme or table. p. 64 - 69. Retrieved 2010/12/29.
• 2、 Avolio, Salvatore,Robertson, Keith,Hernando, Jose Ignacio Martin,DiMuzio, Jillian,Summa, Vincenzo. "Inhibitors of hepatitis C virus NS3/4A: α-Ketoamide based macrocyclic inhibitors". scheme or table. p. 2295 - 2298. Retrieved 2009/12/31.