Cyclohexanemethanamine, 4,4-difluoro-

Base Information

• Chemical Name: Cyclohexanemethanamine, 4,4-difluoro-
• CAS No.: 810659-05-3
• Molecular Formula: C7H13F2N
• Molecular Weight: 149.184
• Hs Code.: 2921300090
• Mol file: 810659-05-3.mol

Synonyms:(4,4-Difluorocyclohexyl)methanamine;1-(Aminomethyl)-4,4-difluorocyclohexane;

Chemical Property of Cyclohexanemethanamine, 4,4-difluoro-

Chemical Property:

• Vapor Pressure: 1.45mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 170.7 °C at 760 mmHg
• Flash Point: 65.1 °C
• PSA: 26.02000
• Density: 1.05 g/cm³
• LogP: 2.47090

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4,4-Difluorocyclohexyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanemethanamine, 4,4-difluoro-

There total 9 articles about Cyclohexanemethanamine, 4,4-difluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,4-difluorocyclohexane-1-carbonitrile (922728-21-0) → 1-(4,4-difluorocyclohexyl)methanamine (810659-05-3)

Guidance literature:

With hydrogen; Raney 2800 nickel; In ethanol; water; under 2585.81 Torr; Product distribution / selectivity;

Reference yield: 82.0%

4,4-difluorocyclohexanecarboxamide (927209-98-1) → 1-(4,4-difluorocyclohexyl)methanamine (810659-05-3)

Guidance literature:

4,4-difluorocyclohexanecarboxamide; With lithium borohydride; Heating / reflux;

With water; at 0 ℃;

Reference yield:

tert-butyl (4,4-difluorocyclohexyl)methylcarbamate (809273-64-1) → 1-(4,4-difluorocyclohexyl)methanamine (810659-05-3)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; for 2h;

upstream raw materials:

8,8-difluoro-1,4-dioxaspiro[4,5]decane

diethyl ether

4,4-difluorocyclohexanone

4,4-difluorocyclohexane-1-carbonitrile

Downstream raw materials:

5-bromo-7-chloro-2-[(4,4-difluorocyclohexyl)methyl]isoindolin-1-one

C₂₀H₂₃ClF₂N₄O

N-((4,4-difluorocyclohexyl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine

Refernces

• 1、 -. "Substituted imidazo[1,2-b]pyridazines as protein kinase inhibitors". Page/Page column 134; 135. . Retrieved 2016/09/13.
• 2、 -. "SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS". Page/Page column 18. . Retrieved 2009/05/29.