Technology Process of (3S)-N-{[3-(benzyloxycarbonyl)amino]-2-oxopiperidin-1-yl}-N-methylcyanamide
There total 9 articles about (3S)-N-{[3-(benzyloxycarbonyl)amino]-2-oxopiperidin-1-yl}-N-methylcyanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium acetate;
In
methanol;
at 20 ℃;
for 7h;
DOI:10.1021/ol3030583
- Guidance literature:
-
Multi-step reaction with 3 steps
1: magnesium sulfate; acetic acid / tetrahydrofuran; water / 4 h / 20 °C
2: sodium cyanoborohydride / tetrahydrofuran; acetic acid / 0 - 20 °C
3: sodium acetate / methanol / 7 h / 20 °C
With
sodium acetate; sodium cyanoborohydride; magnesium sulfate; acetic acid;
In
tetrahydrofuran; methanol; water; acetic acid;
DOI:10.1021/ol3030583
- Guidance literature:
-
Multi-step reaction with 9 steps
1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: tert.-butylnitrite / acetonitrile / 1.5 h / Reflux
3: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / 0 °C
4: sodium tetrahydroborate / methanol / 0.33 h / 0 °C
5: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C
6: hydrazine hydrate / methanol / 24.75 h / 20 °C
7: magnesium sulfate; acetic acid / tetrahydrofuran; water / 4 h / 20 °C
8: sodium cyanoborohydride / tetrahydrofuran; acetic acid / 0 - 20 °C
9: sodium acetate / methanol / 7 h / 20 °C
With
4-methyl-morpholine; sodium tetrahydroborate; tert.-butylnitrite; hydrazine hydrate; carbon tetrabromide; sodium acetate; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol3030583
