4-chloropyrrolo[1,2-f][1,2,4]triazine

Base Information

• Chemical Name: 4-chloropyrrolo[1,2-f][1,2,4]triazine
• CAS No.: 888720-29-4
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.571
• Hs Code.: 2933990090
• Mol file: 888720-29-4.mol

Synonyms:4-chloropyrrolo[1,2-f][1,2,4]triazine;Pyrrolo[2,1-f][1,2,4]triazine,4-chloro-;4-Chloropyrrolo[1,2-f][1,...;4-chloropyrrolo[1;4-Chloropyrrolo[2,1-f][1,2,4]triazine

Chemical Property of 4-chloropyrrolo[1,2-f][1,2,4]triazine

Chemical Property:

• Refractive Index: 1.791
• PKA: -2.85±0.30(Predicted)
• PSA: 30.19000
• Density: 1.51 g/cm³
• LogP: 1.38270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloropyrrolo[2,1-f][1,2,4]triazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloropyrrolo[1,2-f][1,2,4]triazine is a pyrrolotriazine derivative used in the preparation of kinase inhibitors for treating cancer.

Technology Process of 4-chloropyrrolo[1,2-f][1,2,4]triazine

There total 8 articles about 4-chloropyrrolo[1,2-f][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one (159326-71-3) → 4-chloropyrrolo[1,2-f][1,2,4]triazine (888720-29-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In toluene; at 120 ℃; for 24h;

Reference yield: 61.6%

pyrrolo[1,2-f][1,2,4]triazin-4-ol (159326-71-3) → 4-chloropyrrolo[1,2-f][1,2,4]triazine (888720-29-4)

Guidance literature:

pyrrolo[1,2-f][1,2,4]triazin-4-ol; With N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate; In acetonitrile; at 80 ℃; for 16h;

With water; Cooling;

Reference yield:

pyrrolo[1,2-f][1,2,4]triazin-4(1H)-one → 4-chloropyrrolo[1,2-f][1,2,4]triazine (888720-29-4)

Guidance literature:

With trichlorophosphate; at 60 ℃;

upstream raw materials:

pyrrolo<2,1-f><1,2,4>triazin-4(3H)-one

pyrrolo[1,2-f][1,2,4]triazin-4-ol

N-(1H-pyrrol-1-yl)-carbamic acid tert-butyl ester

tert-butyl (2-cyano-1H-pyrrol-1-yl)carbamate

Downstream raw materials:

ethyl 3-(5-(pyrrolo[2,1-f][1,2,4]-triazin-4-ylamino)-2H-pyrazol-3-ylthio)benzoate

(2R,3R,4R,5R)‐2‐{4‐aminopyrrolo[2,1‐f][1,2,4]triazin‐7‐yl}‐3,4‐bis(benzyloxy)‐5‐[(benzyloxy)methyl]tetrahydrofuran‐2‐carbonitrile

7-iodopyrrolo-[2,1-f][1,2,4]-triazin-4-amine

pyrrolo[2,1-f][1,2,4]triazin-4-amine

Refernces

• 1、 -. "Novel synthesis method of compound 7-iodopyrrolo[2, 1-f][1, 2, 4]triazin-4-amine". Paragraph 0046-0048. . Retrieved 2021/09/04.
• 2、 -. "BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS". Paragraph 00232. . Retrieved 2020/08/22.