Multi-step reaction with 10 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C
2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere
3: sodium carbonate / water / 24 h / 0 - 20 °C
4: zinc; ammonium chloride / methanol / 1 h / 50 °C
5: ethanol / 3 h / 20 °C / Inert atmosphere
6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere
7: dichloromethane / 7 h / 0 - 20 °C
8: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
9: piperidine / 12 h / 90 °C / Sealed tube
10: dimedone; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 6 h / 20 °C
With
piperidine; tetrakis(triphenylphosphine) palladium(0); sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; benzotriazol-1-ol; dimedone; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; zinc;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;