7-N-BOC-AMINO-INDOLE

Base Information

• Chemical Name: 7-N-BOC-AMINO-INDOLE
• CAS No.: 886365-44-2
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Hs Code.: 2933990090
• Mol file: 886365-44-2.mol

Synonyms:(1H-Indol-7-yl)carbamic acid tert-butyl ester

Chemical Property of 7-N-BOC-AMINO-INDOLE

Chemical Property:

• Vapor Pressure: 4.42E-05mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 350.4°C at 760 mmHg
• PKA: 14.68±0.43(Predicted)
• Flash Point: 165.7°C
• PSA: 54.12000
• Density: 1.216g/cm³
• LogP: 3.58790
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl1H-indol-7-ylcarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-N-BOC-AMINO-INDOLE

There total 2 articles about 7-N-BOC-AMINO-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

di-tert-butyl dicarbonate (24424-99-5) + 7-aminoindole (5192-04-1) → tert-butyl (1H-indol-7-yl)carbamate (886365-44-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

DOI:10.1021/acs.orglett.6b00634

Reference yield:

7-nitro-1H-indole (6960-42-5) → tert-butyl (1H-indol-7-yl)carbamate (886365-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: zinc; ammonium chloride / methanol / 12 h / 20 °C

2: triethylamine / 12 h / 20 °C

With ammonium chloride; triethylamine; zinc; In methanol;

upstream raw materials:

di-tert-butyl dicarbonate

7-aminoindole

7-nitro-1H-indole

Refernces

• 1、 Martinez-Ariza, Guillermo,McConnell, Nicholas,Hulme, Christopher. "One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines". supporting information. p. 1864 - 1867. Retrieved 2016/05/19.